https://scholars.lib.ntu.edu.tw/handle/123456789/410734
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Chang R. | en_US |
dc.contributor.author | Tsai W.-B. | en_US |
dc.creator | Chang R.;Tsai W.-B. | - |
dc.date.accessioned | 2019-05-28T01:53:23Z | - |
dc.date.available | 2019-05-28T01:53:23Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 20734360 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/410734 | - |
dc.description.abstract | Temperature stimulus, easy modulation in comparison to other environmental stimuli, makes thermo-responsive nanocarriers popular in the applications of controlled drug release for cancer therapy. In this study, photosensitive sodium copper chlorophyllin (SCC) was incorporated into thermo-responsive polymeric nanogels consisted of N-isopropylacrylamide and N-(hydroxymethyl)acrylamide. Significant heat was generated from the SCC-containing nanogels under the exposure to 532-nm green laser, and resulted in cell mortality. The thermo-responsive nanogel loaded with 5-FU, an anti-cancer drug, released the drug explosively when exposed to green laser. The combination of hyperthermia and temperature-induced drug release via green laser irradiation greatly enhanced cell mortality to a maximal extent. Such photothermo-responsive nanogel possesses a great potential in anti-cancer treatment. ? 2018 by the authors. | - |
dc.language | English | - |
dc.relation.ispartof | Polymers | en_US |
dc.subject | Anti-cancer | - |
dc.subject | Drug delivery | - |
dc.subject | N-isopropylacrylamide | - |
dc.subject | Nanogel | - |
dc.subject | Photothermo-responsive | - |
dc.subject | Sodium copper chlorophyllin | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | Acrylic monomers; Amides; Diseases; Drug delivery; Nanostructured materials; Oncology; Targeted drug delivery; Anti-cancer; N- isopropylacrylamide; Nanogels; Photothermo-responsive; Sodium copper chlorophyllin; Controlled drug delivery | - |
dc.title | Fabrication of photothermo-responsive drug-loaded nanogel for synergetic cancer therapy | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.3390/polym10101098 | - |
dc.identifier.scopus | 2-s2.0-85054504119 | - |
dc.identifier.url | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85054504119&doi=10.3390%2fpolym10101098&partnerID=40&md5=544c0fe4873d78179aa05e4ee87a3512 | - |
dc.relation.journalvolume | 10 | - |
dc.relation.journalissue | 10 | - |
item.openairetype | journal article | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Chemical Engineering | - |
crisitem.author.orcid | 0000-0002-2316-5751 | - |
crisitem.author.parentorg | College of Engineering | - |
顯示於: | 化學工程學系 |
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