https://scholars.lib.ntu.edu.tw/handle/123456789/411230
標題: | Cembranoid-related metabolites and biological activities from the soft coral sinularia flexibilis | 作者: | Wu, Chia Hua Chao, Chih Hua Huang, Tzu Zin Huang, Chiung Yao Hwang, Tsong Long CHANG-FENG DAI Sheu, Jyh Horng |
關鍵字: | Cembranoid-related compounds | Flexibilisin | Flexibilisolide | Secoflexibilisolide | Sinularia flexibilis;Cembranoid-related compounds; Flexibilisin; Flexibilisolide; Secoflexibilisolide; Sinularia flexibilis | 公開日期: | 9-八月-2018 | 出版社: | MDPI | 卷: | 16 | 期: | 8 | 來源出版物: | Marine Drugs | 摘要: | © 2018 by the authors. Five new cembranoid-related diterpenoids, namely, flexibilisins D and E (1 and 2), secoflexibilisolides A and B (3 and 4), and flexibilisolide H (5), along with nine known compounds (6–14), were isolated from the soft coral Sinularia flexibilis. Their structures were established by extensive spectral analysis. Compound 3 possesses an unusual skeleton that could be biogenetically derived from cembranoids. The cytotoxicity and anti-inflammatory activities of the isolates were investigated, and the results showed that dehydrosinulariolide (7) and 11-epi-sinulariolide acetate (8) exhibited cytotoxicity toward a limited panel of cancer cell lines and 14-deoxycrassin (9) displayed anti-inflammatory activity by inhibition of superoxide anion generation and elastase release in N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLF/CB)-induced human neutrophils. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/411230 | ISSN: | 1660-3397 | DOI: | 10.3390/md16080278 | SDG/關鍵字: | 11 dehydrosinulariolide; 11 epi sinulariolide acetate; 14 deoxycrassin; 3,4:8,11 bisepoxy 7 acetoxycembra 15(17) en 1,12 olide; antiinflammatory agent; cembranoid; cytotoxic agent; doxorubicin; drug metabolite; elastase; flexibilisin D; flexibilisin E; flexibilisolide H; flexibilisquinone; hydroxysinulariolide; querciformolide A; secoflexibilisolide A; secoflexibilisolide B; sinulaflexiolide E; sinulariolide; superoxide; unclassified drug; antiinflammatory agent; antineoplastic agent; cytochalasin B; diterpene; formylmethionylleucylphenylalanine; pancreatic elastase; superoxide; antiinflammatory activity; antineoplastic activity; Article; cancer cell destruction; cancer cell line; carbon nuclear magnetic resonance; controlled study; coral; cytotoxicity; drug structure; electrospray mass spectrometry; enzyme release; heteronuclear multiple bond correlation; high performance liquid chromatography; HT-29 cell line; human; hydrolysis; IC50; in vitro study; inhibition kinetics; K-562 cell line; neutrophil; nonhuman; nuclear Overhauser effect; P388 cell line; proton nuclear magnetic resonance; Sinularia flexibilis; X ray diffraction; animal; Anthozoa; chemistry; drug effect; drug screening; isolation and purification; metabolism; secretion (process); tumor cell line; Animals; Anthozoa; Anti-Inflammatory Agents; Antineoplastic Agents; Cell Line, Tumor; Cytochalasin B; Diterpenes; Drug Screening Assays, Antitumor; Humans; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pancreatic Elastase; Superoxides |
顯示於: | 海洋研究所 |
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