https://scholars.lib.ntu.edu.tw/handle/123456789/411230
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Wu, Chia Hua | en_US |
dc.contributor.author | Chao, Chih Hua | en_US |
dc.contributor.author | Huang, Tzu Zin | en_US |
dc.contributor.author | Huang, Chiung Yao | en_US |
dc.contributor.author | Hwang, Tsong Long | en_US |
dc.contributor.author | CHANG-FENG DAI | en_US |
dc.contributor.author | Sheu, Jyh Horng | en_US |
dc.creator | Huang, Tzu Zin;Chao, Chih Hua;Wu, Chia Hua;Sheu, Jyh Horng;CHANG-FENG DAI;Hwang, Tsong Long;Huang, Chiung Yao | - |
dc.date.accessioned | 2019-06-20T03:14:13Z | - |
dc.date.available | 2019-06-20T03:14:13Z | - |
dc.date.issued | 2018-08-09 | - |
dc.identifier.issn | 1660-3397 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/411230 | - |
dc.description.abstract | © 2018 by the authors. Five new cembranoid-related diterpenoids, namely, flexibilisins D and E (1 and 2), secoflexibilisolides A and B (3 and 4), and flexibilisolide H (5), along with nine known compounds (6–14), were isolated from the soft coral Sinularia flexibilis. Their structures were established by extensive spectral analysis. Compound 3 possesses an unusual skeleton that could be biogenetically derived from cembranoids. The cytotoxicity and anti-inflammatory activities of the isolates were investigated, and the results showed that dehydrosinulariolide (7) and 11-epi-sinulariolide acetate (8) exhibited cytotoxicity toward a limited panel of cancer cell lines and 14-deoxycrassin (9) displayed anti-inflammatory activity by inhibition of superoxide anion generation and elastase release in N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLF/CB)-induced human neutrophils. | en_US |
dc.language.iso | en | en_US |
dc.publisher | MDPI | en_US |
dc.relation.ispartof | Marine Drugs | en_US |
dc.subject | Cembranoid-related compounds | Flexibilisin | Flexibilisolide | Secoflexibilisolide | Sinularia flexibilis | en_US |
dc.subject | Cembranoid-related compounds; Flexibilisin; Flexibilisolide; Secoflexibilisolide; Sinularia flexibilis | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | 11 dehydrosinulariolide; 11 epi sinulariolide acetate; 14 deoxycrassin; 3,4:8,11 bisepoxy 7 acetoxycembra 15(17) en 1,12 olide; antiinflammatory agent; cembranoid; cytotoxic agent; doxorubicin; drug metabolite; elastase; flexibilisin D; flexibilisin E; flexibilisolide H; flexibilisquinone; hydroxysinulariolide; querciformolide A; secoflexibilisolide A; secoflexibilisolide B; sinulaflexiolide E; sinulariolide; superoxide; unclassified drug; antiinflammatory agent; antineoplastic agent; cytochalasin B; diterpene; formylmethionylleucylphenylalanine; pancreatic elastase; superoxide; antiinflammatory activity; antineoplastic activity; Article; cancer cell destruction; cancer cell line; carbon nuclear magnetic resonance; controlled study; coral; cytotoxicity; drug structure; electrospray mass spectrometry; enzyme release; heteronuclear multiple bond correlation; high performance liquid chromatography; HT-29 cell line; human; hydrolysis; IC50; in vitro study; inhibition kinetics; K-562 cell line; neutrophil; nonhuman; nuclear Overhauser effect; P388 cell line; proton nuclear magnetic resonance; Sinularia flexibilis; X ray diffraction; animal; Anthozoa; chemistry; drug effect; drug screening; isolation and purification; metabolism; secretion (process); tumor cell line; Animals; Anthozoa; Anti-Inflammatory Agents; Antineoplastic Agents; Cell Line, Tumor; Cytochalasin B; Diterpenes; Drug Screening Assays, Antitumor; Humans; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pancreatic Elastase; Superoxides | - |
dc.title | Cembranoid-related metabolites and biological activities from the soft coral sinularia flexibilis | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.3390/md16080278 | - |
dc.identifier.pmid | 30096866 | - |
dc.identifier.scopus | 2-s2.0-85053718532 | - |
dc.identifier.isi | WOS:000442868200005 | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/85053718532 | - |
dc.relation.journalvolume | 16 | en_US |
dc.relation.journalissue | 8 | en_US |
item.openairetype | journal article | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
crisitem.author.orcid | 0000-0003-2242-5643 | - |
顯示於: | 海洋研究所 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。