https://scholars.lib.ntu.edu.tw/handle/123456789/413274
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Li T.-Y. | en_US |
dc.contributor.author | Chiang B.-H. | en_US |
dc.creator | Chiang B.-H.;Li T.-Y. | - |
dc.date.accessioned | 2019-07-11T02:14:42Z | - |
dc.date.available | 2019-07-11T02:14:42Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 07533322 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/413274 | - |
dc.description.abstract | 6-shogaol is a phytochemical of dietary ginger, we found that 6-shogaol could induced both autophagic and apoptotic death in human colon adenocarcinoma (HT-29) cells. Results of this study showed that 6-shogal induced cell cycle arrest, autophagy, and apoptosis in HT-29 cells in a time sequence. After 6?h, 6-shogal induced apparent G2/M arrest, then the HT-29 cells formed numerous autophagosomes in each phase of the cell cycle. After 18?h, increases in acidic vesicles and LAMP-1 (Lysosome-associated membrane proteins 1) showed that 6-shogaol had caused autophagic cell death. After 24?h, cell shrinkage and Caspase-3/7 activities rising, suggesting that apoptotic cell death had increased. And after 48?h, the result of TUNEL assay indicated the highest occurrence of apoptosis upon 6-shogaol treatment. It appeared that apoptosis is triggered by autophagy in 6-shogaol treated HT-29 cells, the damage of autophagic cell death initiated apoptosis program. ? 2017 Elsevier Masson SAS | - |
dc.language | English | - |
dc.relation.ispartof | Biomedicine and Pharmacotherapy | - |
dc.subject | 6-shogaol | - |
dc.subject | Apoptosis | - |
dc.subject | Autophagy | - |
dc.subject | Colorectal cancer | - |
dc.subject | HT 29 | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | caspase 3; caspase 7; shogaol; caspase 3; caspase 7; catechol derivative; reactive oxygen metabolite; shogaol; apoptosis; Article; autolysosome; autophagosome; autophagy; cell culture; cell cycle arrest; cell cycle assay; cell death; cell viability; colorectal carcinoma; controlled study; DNA damage; enzyme activity; G2 phase cell cycle checkpoint; HT-29 cell line; human; human cell; immunocytochemistry; lysosome membrane; M phase cell cycle checkpoint; priority journal; TUNEL assay; adenocarcinoma; apoptosis; cell cycle checkpoint; cell death; chemistry; colorectal tumor; drug effects; ginger; metabolism; signal transduction; tumor cell line; Adenocarcinoma; Apoptosis; Autophagy; Caspase 3; Caspase 7; Catechols; Cell Cycle Checkpoints; Cell Death; Cell Line, Tumor; Colorectal Neoplasms; G2 Phase Cell Cycle Checkpoints; Ginger; HT29 Cells; Humans; Reactive Oxygen Species; Signal Transduction | - |
dc.title | 6-shogaol induces autophagic cell death then triggered apoptosis in colorectal adenocarcinoma HT-29 cells | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1016/j.biopha.2017.06.038 | - |
dc.identifier.scopus | 2-s2.0-85020863726 | - |
dc.identifier.url | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85020863726&doi=10.1016%2fj.biopha.2017.06.038&partnerID=40&md5=7239f80b51a5796a88e5e6b7c8fdb0e7 | - |
dc.relation.pages | 208-217 | - |
dc.relation.journalvolume | 93 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Food Science and Technology | - |
crisitem.author.orcid | 0000-0002-0573-5650 | - |
crisitem.author.parentorg | College of Bioresources and Agriculture | - |
顯示於: | 食品科技研究所 |
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