https://scholars.lib.ntu.edu.tw/handle/123456789/413276
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Chou K.C.-C. | en_US |
dc.contributor.author | Yang S.-H. | en_US |
dc.contributor.author | Wu H.-L. | en_US |
dc.contributor.author | Lin P.-Y. | en_US |
dc.contributor.author | Chang T.-L. | en_US |
dc.contributor.author | Sheu F. | en_US |
dc.contributor.author | Chen K.-H. | en_US |
dc.contributor.author | FUU SHEU | en_US |
dc.creator | Chiang B.-H.;Chen K.-H.;Sheu F.;Chang T.-L.;Lin P.-Y.;Wu H.-L.;Yang S.-H.;Chou K.C.-C. | - |
dc.date.accessioned | 2019-07-11T02:14:43Z | - |
dc.date.available | 2019-07-11T02:14:43Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 00218561 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/413276 | - |
dc.description.abstract | Antroquinonol (AQ) and 4-acetylantroquinonol B (4-AAQB), isolated from the mycelium of Antrodia cinnamomea, have a similar chemical backbone to coenzyme Q (CoQ). Based on the postulation that biosynthesis of both AQ and 4-AAQB in A. cinnamomea starts from the polyketide pathway, we cultivated this fungus in a culture medium containing [U-13C]oleic acid, and then we analyzed the crude extracts of the mycelium using UHPLC-MS. We found that AQ and 4-AAQB follow similar biosynthetic sequences as CoQ. Obvious [13C2] fragments on the ring backbone were detected in the mass spectrum for [13C2]AQ, [13C2]4-AAQB, and their [13C2] intermediates found in this study. The orsellinic acid, formed from acetyl-CoA and malonyl-CoA via the polyketide pathway, was found to be a novel benzoquinone ring precursor for AQ and 4- AAQB. The identification of endogenously synthesized farnesylated intermediates allows us to postulate the routes of AQ and 4- AAQB biosynthesis in A. cinnamomea. ? 2016 American Chemical Society. | - |
dc.language | English | - |
dc.relation.ispartof | Journal of Agricultural and Food Chemistry | - |
dc.subject | 4-acetylantroquinonol B | - |
dc.subject | Antrodia cinnamomea | - |
dc.subject | Antroquinonol | - |
dc.subject | Orsellinic acid | - |
dc.subject | Polyketide pathway | - |
dc.title | Biosynthesis of Antroquinonol & 4-Acetylantroquinonol B via a Polyketide pathway using orsellinic acid as a ring precursor in Antrodia cinnamomea | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1021/acs.jafc.6b04346 | - |
dc.identifier.scopus | 2-s2.0-85016436867 | - |
dc.identifier.url | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85016436867&doi=10.1021%2facs.jafc.6b04346&partnerID=40&md5=189e9d40be753b93e03c66b001835524 | - |
dc.relation.pages | 74-86 | - |
dc.relation.journalvolume | 65 | - |
dc.relation.journalissue | 1 | - |
item.openairetype | journal article | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Horticulture and Landscape Architecture | - |
crisitem.author.dept | Center for Biotechnology | - |
crisitem.author.orcid | 0000-0001-9794-3483 | - |
crisitem.author.parentorg | College of Bioresources and Agriculture | - |
crisitem.author.parentorg | Others: University-Level Research Centers | - |
顯示於: | 食品科技研究所 |
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