https://scholars.lib.ntu.edu.tw/handle/123456789/413358
Title: | The treatment of autoimmune disease in (NZB/NZW)F1 mice with syngeneic photomodulated splenocytes | Authors: | LI-FANG WANG | Issue Date: | May-1994 | Journal Volume: | 39 | Journal Issue: | 5 | Source: | Scandinavian journal of immunology | Abstract: | (NZB x NZW)F1 (B/W) mice spontaneously develop a disease which is remarkably similar to systemic lupus erythematosus (SLE) in humans. This disease is characterized by the appearance of autoantibodies to double-stranded (ds)DNA and the subsequent development of fatal glomerulonephritis. The prophylactic treatment of B/W mice with syngeneic photomodulated autoimmune spleen cells was found to significantly improve survival, and to inhibit the outgrowth of autoreactive B cells and the production of high-titre IgG anti-dsDNA antibodies. The function of the autoreactive T cells in vivo, however, did not change significantly. Our findings suggested a novel treatment for spontaneously occurring autoantibody-related autoimmune diseases. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/413358 | ISSN: | 0300-9475 | DOI: | https://api.elsevier.com/content/abstract/scopus_id/0028338925 10.1111/j.1365-3083.1994.tb03399.x |
SDG/Keyword: | autoantibody; dna antibody; immunoglobulin g; interleukin 2; animal experiment; article; autoimmunity; b lymphocyte; enzyme linked immunosorbent assay; female; immunization; mouse; nonhuman; photoreactivity; spleen cell; systemic lupus erythematosus; t lymphocyte; Animal; Antibodies, Antinuclear; Autoimmune Diseases; B-Lymphocytes; Enzyme-Linked Immunosorbent Assay; Female; Mice; Mice, Inbred NZB; Mice, Inbred Strains; Photopheresis; Spleen; Support, Non-U.S. Gov't |
Appears in Collections: | 醫學系 |
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