|Title:||The 4-acetylantroquinonol B isolated from mycelium of Antrodia cinnamomea inhibits proliferation of hepatoma cells||Authors:||Lin Y.-W.
|Keywords:||4-acetylantroquinonol B;Antiproliferation;Antrodia cinnamomea;Hepatoma cells;Submerged fermentation||Issue Date:||2010||Source:||Journal of the Science of Food and Agriculture||Journal Volume:||90||Journal Issue:||10||Start page/Pages:||1739-1744||Abstract:||
BACKGROUND: Antrodia cinnamomea is known for its antihepatoma activity, yet the identity of its active compound was unclear. In this study, a 5-ton fermenter was used to prepare sufficient mycelium of A. cinnamomea for active compound isolation and identification. RESULTS: Using antiproliferative activity toward HepG2 cells as guidance in the isolation process, 4-acetylantroquinonol B was purified and identified to be the major bioactive compound of A. cinnamomea cultivated by submerged fermentation. The median effective doses (EC50) of 4-acetylantroquinonol B for HepG2 cells were 0.10 ¡? 0.00 and 0.08 ¡? 0.00 £gg mL-1 for 72 and 96 h treatments, respectively. The selective indices of 4-acetylantroquinonol B were 100 and 125 for 72 and 96 h treatments, respectively, indicating that this compound had high selective activity for hepatoma cells. CONCLUSION: 4-Acetylantroquinonol B is the major antihepatoma constituent of Antrodia cinnamomea mycelium produced by submerged fermentation. ? 2010 Society of Chemical Industry.
|Appears in Collections:||食品科技研究所|
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