https://scholars.lib.ntu.edu.tw/handle/123456789/413601
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Chen H.-W. | en_US |
dc.contributor.author | Ko J.-J. | en_US |
dc.contributor.author | Lii C.-K. | en_US |
dc.contributor.author | Ou C.-C. | en_US |
dc.contributor.author | Sheen L.-Y. | en_US |
dc.creator | Sheen L.-Y.;Ou C.-C.;Lii C.-K.;Ko J.-J.;Chen H.-W. | - |
dc.date.accessioned | 2019-07-11T09:16:50Z | - |
dc.date.available | 2019-07-11T09:16:50Z | - |
dc.date.issued | 1997 | - |
dc.identifier.issn | 1635581 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/413601 | - |
dc.description.abstract | We investigated the effects of type of dietary fat and phenobarbital on £^-glutamyl transpeptidase-positive foci development. Four groups of six female Sprague-Dawley rats were initiated with diethylnitrosamine (15 mg/kg) at 24 hours of age. After weaning, they were fed nutritionally complete semipurified diets containing 15% corn oil or 5% corn oil + 10% fish oil and supplemented with 5,000 ppm vitamin E with or without phenobarbital (500 ppm) for three months. Dietary fish oil significantly increased hepatic phospholipid eicosapentaenoate and docosahexaenoate concentrations and decreased arachidonate concentration compared with 15% corn oil (p < 0.05). Corn oil (15%) significantly increased hepatic prostaglandin F2£\ concentration compared with 10% fish oil (p < 0.05). Phenobarbital significantly stimulated glutathione S-transferase activity in both dietary fat groups (p < 0.05). In the absence of phenobarbital, type of dietary fat showed no effect on hepatic £^-glutamyl transpeptidase-positive loci development. However, in the presence of phenobarbital, 15% corn oil significantly enhanced £^-glutamyl transpeptidase-positive foci development compared with 10% fish oil (p < 0.05). Phenobarbital showed a strong tumor- promoting action in both dietary groups. In conclusion, there was an interaction between type of dietary fat and phenobarbital on £^-glutamyl transpeptidase-positive foci development during hepatocar- cinogenesis in rats. | - |
dc.language | English | - |
dc.relation.ispartof | Nutrition and Cancer | - |
dc.title | Corn oil enhances £^-glutamyl transpeptidase-positive foci development in the presence of phenobarbital during hepatocarcinogenesis in rats | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1080/01635589709514584 | - |
dc.identifier.scopus | 2-s2.0-0030840583 | - |
dc.identifier.url | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0030840583&doi=10.1080%2f01635589709514584&partnerID=40&md5=f55f2ac1636587ba3e20bc42ef139646 | - |
dc.relation.pages | 252-257 | - |
dc.relation.journalvolume | 28 | - |
dc.relation.journalissue | 3 | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.cerifentitytype | Publications | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
crisitem.author.dept | Food Science and Technology | - |
crisitem.author.orcid | 0000-0001-5541-652X | - |
crisitem.author.parentorg | College of Bioresources and Agriculture | - |
顯示於: | 食品科技研究所 |
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