DC 欄位 | 值 | 語言 |
dc.contributor.author | Lin I.-Y. | en_US |
dc.contributor.author | Chiou Y.-S. | en_US |
dc.contributor.author | Wu L.-C. | en_US |
dc.contributor.author | Tsai C.-Y. | en_US |
dc.contributor.author | Chen C.-T. | en_US |
dc.contributor.author | Chuang W.-C. | en_US |
dc.contributor.author | Lee M.-C. | en_US |
dc.contributor.author | Lin C.-C. | en_US |
dc.contributor.author | Lin T.-T. | en_US |
dc.contributor.author | Chen S.-C. | en_US |
dc.contributor.author | Pan M.-H. | en_US |
dc.contributor.author | MIN-HSIUNG PAN | en_US |
dc.creator | Ma N.;Pan M.-H.;Chen S.-C.;Lin T.-T.;Lin C.-C.;Lee M.-C.;Chuang W.-C.;Chen C.-T.;Tsai C.-Y.;Wu L.-C.;Chiou Y.-S.;Lin I.-Y. | - |
dc.date.accessioned | 2019-07-12T07:09:17Z | - |
dc.date.available | 2019-07-12T07:09:17Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 10219498 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/413617 | - |
dc.description.abstract | CCM111 is an aqueous extract of Antrodia cinnamomea (AC) that has exhibited anti-liver fibrosis functions. However, the detailed mechanisms of AC action against liver fibrosis have not been elucidated yet. The present research showed that CCM111 significantly lowered the levels of the hepatic enzyme markers glutamate oxaloacetate transaminase (GOT) and glutamic pyruvic transaminase (GPT), prevented liver damage and collagen deposition, and downregulated TGF-£]/Smad signaling in a dose-dependent manner compared with CCl 4 treatment alone. CCM111 markedly inhibited TGF-£] Wnt and STAT3 signaling pathway-regulated downstream genes in the liver by next-generation sequencing. The antifibrotic mechanisms of CCM111 were further demonstrated in HSC-T6 cells. Our data demonstrated for the first time that CCM111 can protect against CCl 4 -induced liver fibrosis by the cooperative inhibition of TGF-£]-, Wnt- and STAT3-dependent proinflammatory and profibrotic mediators, suggesting that CCM111 might be a candidate for preventing and treating chronic fibrotic liver diseases. ? 2018 | en_US |
dc.language | English | - |
dc.relation.ispartof | Journal of Food and Drug Analysis | en_US |
dc.subject | Antrodia cinnamomea | en_US |
dc.subject | Liver fibrosis | en_US |
dc.subject | STAT3 pathway | en_US |
dc.subject | TGF-£] pathway | en_US |
dc.subject | Wnt pathway | en_US |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | alanine aminotransferase; alpha smooth muscle actin; Antrodia cinnamomea extract; aspartate aminotransferase; beta catenin; carbon tetrachloride; ccm 111; collagen; fungal extract; gelatinase A; silymarin; Smad2 protein; Smad3 protein; STAT3 protein; transforming growth factor beta; unclassified drug; Wnt protein; herbaceous agent; immunoglobulin enhancer binding protein; STAT3 protein; Stat3 protein, mouse; transforming growth factor beta; Wnt protein; animal experiment; animal model; animal tissue; antifibrotic activity; Antrodia camphorata; Article; controlled study; dose response; down regulation; drug cytotoxicity; drug effect; drug mechanism; gene expression; histopathology; HSC-T6 cell line; inflammation; liver fibrosis; liver injury; liver protection; male; mouse; next generation sequencing; nonhuman; protein expression; protein phosphorylation; rat; regulatory mechanism; signal transduction; animal; Antrodia; chemistry; genetics; human; Institute for Cancer Research mouse; liver; liver cirrhosis; metabolism; Animals; Antrodia; Drugs, Chinese Herbal; Humans; Liver; Liver Cirrhosis; Male; Mice; Mice, Inbred ICR; NF-kappa B; Signal Transduction; STAT3 Transcription Factor; Transforming Growth Factor beta; Wnt Proteins | - |
dc.title | CCM111 prevents hepatic fibrosis via cooperative inhibition of TGF-£] Wnt and STAT3 signaling pathways | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1016/j.jfda.2018.09.008 | - |
dc.identifier.doi | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85055741136&doi=10.1016%2fj.jfda.2018.09.008&partnerID=40&md5=873ba8d066e142c56e46886c66653cab | - |
dc.identifier.scopus | 2-s2.0-85055741136 | - |
dc.identifier.url | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85055741136&doi=10.1016%2fj.jfda.2018.09.008&partnerID=40&md5=873ba8d066e142c56e46886c66653cab | - |
dc.relation.pages | 184-194 | en_US |
dc.relation.journalvolume | 27 | en_US |
dc.relation.journalissue | 1 | en_US |
item.fulltext | with fulltext | - |
item.cerifentitytype | Publications | - |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | open | - |
crisitem.author.dept | Food Science and Technology | - |
crisitem.author.dept | Food Science and Technology | - |
crisitem.author.orcid | 0000-0002-5188-7030 | - |
crisitem.author.orcid | 0000-0002-5188-7030 | - |
crisitem.author.parentorg | College of Bioresources and Agriculture | - |
crisitem.author.parentorg | College of Bioresources and Agriculture | - |
顯示於: | 食品科技研究所
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