https://scholars.lib.ntu.edu.tw/handle/123456789/413623
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Lai C.-S. | en_US |
dc.contributor.author | Yang G. | en_US |
dc.contributor.author | Li S. | en_US |
dc.contributor.author | Lee P.-S. | en_US |
dc.contributor.author | Wang B.N. | en_US |
dc.contributor.author | Chung M.-C. | en_US |
dc.contributor.author | Nagabhushanam K. | en_US |
dc.contributor.author | Ho C.-T. | en_US |
dc.contributor.author | MIN-HSIUNG PAN | en_US |
dc.creator | Pan M.-H.;Ho C.-T.;Nagabhushanam K.;Chung M.-C.;Wang B.N.;Lee P.-S.;Li S.;Yang G.;Lai C.-S. | - |
dc.date.accessioned | 2019-07-12T07:09:19Z | - |
dc.date.available | 2019-07-12T07:09:19Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 00218561 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/413623 | - |
dc.description.abstract | 3¡¬-Hydroxypterostilbene (trans-3,5-dimethoxy-3¡¬,4¡¬-hydroxystilbene) presents in Sphaerophysa salsula, Pterocarpus marsupium, and honey bee propolis and has been reported to exhibit several biological activities. Herein, we aimed to explore the chemopreventive effects of dietary 3¡¬-hydroxypterostilbene and underlying molecular mechanisms on colitis-associated cancer using the azoxymethane (AOM)/dextran sodium sulfate (DSS) model. 3¡¬-Hydroxypterostilbene administration effectively ameliorated the colon shortening and number of tumors in AOM/DSS-treated mice (3.2 ¡Ó 1.2 of the high-dose treatment versus 13.8 ¡Ó 5.3 of the AOM/DSS group, p < 0.05). Molecular analysis exhibited the anti-inflammatory activity of 3¡¬-hydroxypterostilbene by a significant decrease in the levels of inducible nitric oxide synthase, cyclooxygenase-2, and interleukin-6 (IL-6) (p < 0.05). Moreover, dietary 3¡¬-hydroxypterostilbene also significantly diminished IL-6/signal transducer and activator of transcription signaling and restored colonic suppressor of cytokine signaling 3 levels in the colonic tissue of mice (p < 0.05). Collectively, these results demonstrated for the first time the in vivo chemopreventive efficacy and molecular mechanisms of dietary 3¡¬-hydroxypterostilbene against colitis-associated colonic tumorigenesis. ? 2017 American Chemical Society. | - |
dc.language | English | - |
dc.relation.ispartof | Journal of Agricultural and Food Chemistry | - |
dc.subject | 3¡¬-hydroxypterostilbene | - |
dc.subject | azoxymethane | - |
dc.subject | colitis | - |
dc.subject | dextran sodium sulfate | - |
dc.subject | inflammation | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | Immunology; Mammals; Nitric oxide; Sodium; Sodium sulfate; Sulfur compounds; Anti-inflammatory activity; azoxymethane; Chemopreventive effects; colitis; High-dose treatment; Inducible nitric oxide synthase; inflammation; Suppressor of cytokine signaling 3; Diseases; 3'-hydroxypterostilbene; antineoplastic agent; cyclooxygenase 2; interleukin 6; STAT3 protein; stilbene derivative; animal; carcinogenesis; colitis; colon tumor; complication; disease model; drug effects; genetics; human; Institute for Cancer Research mouse; male; metabolism; mouse; signal transduction; Animals; Anticarcinogenic Agents; Carcinogenesis; Colitis; Colonic Neoplasms; Cyclooxygenase 2; Disease Models, Animal; Humans; Interleukin-6; Male; Mice; Mice, Inbred ICR; Signal Transduction; STAT3 Transcription Factor; Stilbenes | - |
dc.title | 3¡¬-Hydroxypterostilbene Suppresses Colitis-Associated Tumorigenesis by Inhibition of IL-6/STAT3 Signaling in Mice | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1021/acs.jafc.7b03712 | - |
dc.identifier.scopus | 2-s2.0-85033388512 | - |
dc.identifier.url | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85033388512&doi=10.1021%2facs.jafc.7b03712&partnerID=40&md5=bb414fe08008d1b7036284e4cc2be528 | - |
dc.relation.pages | 9655-9664 | - |
dc.relation.journalvolume | 65 | - |
dc.relation.journalissue | 44 | - |
item.fulltext | no fulltext | - |
item.cerifentitytype | Publications | - |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
crisitem.author.dept | Food Science and Technology | - |
crisitem.author.orcid | 0000-0002-5188-7030 | - |
crisitem.author.parentorg | College of Bioresources and Agriculture | - |
顯示於: | 食品科技研究所 |
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