https://scholars.lib.ntu.edu.tw/handle/123456789/413624
標題: | Anti-diabetic activities of cis- and trans-2,3,5,4¡¬-tetrahydroxystilbene 2-O-£]-glucopyranoside from Polygonum multiflorum | 作者: | Tang W. Li S. Liu Y. Wu J.-C. Pan M.-H. Huang M.-T. MIN-HSIUNG PAN Pan, M.-H. |
關鍵字: | 2,3,5,4¡¬-tetrahydroxystilbene glycoside;Hypoglycemic activity;PEPCK;Polygonum multiflorum;Type 2 diabetes | 公開日期: | 2017 | 卷: | 61 | 期: | 8 | 來源出版物: | Molecular Nutrition and Food Research | 摘要: | Scope: Functional foods can be used alone or in combination with existing therapies in preventing and treating type 2 diabetes (T2D). Trans-2,3,5,4¡¬-tetrahydroxystilbene 2-O-£]-glucopyranoside (trans-THSG), a dominant bioactive compound from Polygonum multiflorum (PM)¡Xa popular medicinal food in Asia, has attracted increasing research interests due to its strong antioxidant activity. The content of naturally occurring cis-THSG (cis-2,3,5,4¡¬-tetrahydroxystilbene 2-O-£]-glucopyranoside) was very low in PM root, but was prepared in this study by mimicking the traditional process of PM. The anti-diabetic effects of trans- and cis-THSG were evaluated in T2D to search for more efficacious food ingredient(s). Methods and results: Trans-THSG was chromatographically purified from PM roots and cis-THSG was prepared with our innovative process via exposure of trans-THSG to UV-light. The anti-diabetic effects of both THSGs were tested with HFD-induced male CF-1 diabetic mice. Cis-THSG was found more effective than trans-THSG in hypoglycemic effect and in ameliorating glucose intolerance and insulin resistance. In HepG2 cells, cis-THSG also demonstrated more potent activity than trans-THSG in suppressing transcription of phosphoenopyruvate carboxykinase (PEPCK). Conclusion: Cis-THSG can be an enriched bioactive ingredient in PM roots from post-processing and is significantly more effective against hyperglycemia than trans-THSG. One of the effective pathways was through inhibition of PEPCK. ? 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/413624 | ISSN: | 16134125 | DOI: | 10.1002/mnfr.201600871 | SDG/關鍵字: | 2,3,5,4'-tetrahydroxystilbene 2-O-beta-D-glucopyranoside; antidiabetic agent; enzyme inhibitor; glucoside; PCK2 protein, human; phosphoenolpyruvate carboxykinase (ATP); stilbene derivative; animal; antagonists and inhibitors; chemistry; experimental diabetes mellitus; Fallopia multiflora; genetics; Hep-G2 cell line; human; insulin resistance; lipid diet; male; non insulin dependent diabetes mellitus; Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet, High-Fat; Enzyme Inhibitors; Fallopia multiflora; Glucosides; Hep G2 Cells; Humans; Hypoglycemic Agents; Insulin Resistance; Male; Phosphoenolpyruvate Carboxykinase (ATP); Stilbenes |
顯示於: | 食品科技研究所 |
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