https://scholars.lib.ntu.edu.tw/handle/123456789/413624
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Tang W. | en_US |
dc.contributor.author | Li S. | en_US |
dc.contributor.author | Liu Y. | en_US |
dc.contributor.author | Wu J.-C. | en_US |
dc.contributor.author | Pan M.-H. | en_US |
dc.contributor.author | Huang M.-T. | en_US |
dc.contributor.author | MIN-HSIUNG PAN | en_US |
dc.contributor.author | Pan, M.-H. | en_US |
dc.creator | Ho C.-T.;Huang M.-T.;Pan M.-H.;Wu J.-C.;Liu Y.;Li S.;Tang W. | - |
dc.date.accessioned | 2019-07-12T07:09:19Z | - |
dc.date.available | 2019-07-12T07:09:19Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 16134125 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/413624 | - |
dc.description.abstract | Scope: Functional foods can be used alone or in combination with existing therapies in preventing and treating type 2 diabetes (T2D). Trans-2,3,5,4¡¬-tetrahydroxystilbene 2-O-£]-glucopyranoside (trans-THSG), a dominant bioactive compound from Polygonum multiflorum (PM)¡Xa popular medicinal food in Asia, has attracted increasing research interests due to its strong antioxidant activity. The content of naturally occurring cis-THSG (cis-2,3,5,4¡¬-tetrahydroxystilbene 2-O-£]-glucopyranoside) was very low in PM root, but was prepared in this study by mimicking the traditional process of PM. The anti-diabetic effects of trans- and cis-THSG were evaluated in T2D to search for more efficacious food ingredient(s). Methods and results: Trans-THSG was chromatographically purified from PM roots and cis-THSG was prepared with our innovative process via exposure of trans-THSG to UV-light. The anti-diabetic effects of both THSGs were tested with HFD-induced male CF-1 diabetic mice. Cis-THSG was found more effective than trans-THSG in hypoglycemic effect and in ameliorating glucose intolerance and insulin resistance. In HepG2 cells, cis-THSG also demonstrated more potent activity than trans-THSG in suppressing transcription of phosphoenopyruvate carboxykinase (PEPCK). Conclusion: Cis-THSG can be an enriched bioactive ingredient in PM roots from post-processing and is significantly more effective against hyperglycemia than trans-THSG. One of the effective pathways was through inhibition of PEPCK. ? 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim | - |
dc.language | English | - |
dc.relation.ispartof | Molecular Nutrition and Food Research | - |
dc.subject | 2,3,5,4¡¬-tetrahydroxystilbene glycoside | - |
dc.subject | Hypoglycemic activity | - |
dc.subject | PEPCK | - |
dc.subject | Polygonum multiflorum | - |
dc.subject | Type 2 diabetes | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | 2,3,5,4'-tetrahydroxystilbene 2-O-beta-D-glucopyranoside; antidiabetic agent; enzyme inhibitor; glucoside; PCK2 protein, human; phosphoenolpyruvate carboxykinase (ATP); stilbene derivative; animal; antagonists and inhibitors; chemistry; experimental diabetes mellitus; Fallopia multiflora; genetics; Hep-G2 cell line; human; insulin resistance; lipid diet; male; non insulin dependent diabetes mellitus; Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet, High-Fat; Enzyme Inhibitors; Fallopia multiflora; Glucosides; Hep G2 Cells; Humans; Hypoglycemic Agents; Insulin Resistance; Male; Phosphoenolpyruvate Carboxykinase (ATP); Stilbenes | - |
dc.title | Anti-diabetic activities of cis- and trans-2,3,5,4¡¬-tetrahydroxystilbene 2-O-£]-glucopyranoside from Polygonum multiflorum | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1002/mnfr.201600871 | - |
dc.identifier.scopus | 2-s2.0-85013851088 | - |
dc.identifier.url | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85013851088&doi=10.1002%2fmnfr.201600871&partnerID=40&md5=48abd828fd0227a63eb5540249c27910 | - |
dc.relation.journalvolume | 61 | - |
dc.relation.journalissue | 8 | - |
item.fulltext | no fulltext | - |
item.grantfulltext | none | - |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Food Science and Technology | - |
crisitem.author.dept | Food Science and Technology | - |
crisitem.author.dept | Food Science and Technology | - |
crisitem.author.orcid | 0000-0002-5188-7030 | - |
crisitem.author.orcid | 0000-0002-5188-7030 | - |
crisitem.author.orcid | 0000-0002-5188-7030 | - |
crisitem.author.parentorg | College of Bioresources and Agriculture | - |
crisitem.author.parentorg | College of Bioresources and Agriculture | - |
crisitem.author.parentorg | College of Bioresources and Agriculture | - |
顯示於: | 食品科技研究所 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。