https://scholars.lib.ntu.edu.tw/handle/123456789/414212
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Chen C. | en_US |
dc.contributor.author | Li C. | en_US |
dc.contributor.author | Wang Y. | en_US |
dc.contributor.author | Renaud J. | en_US |
dc.contributor.author | Tian G. | en_US |
dc.contributor.author | Kambhampati S. | en_US |
dc.contributor.author | Saatian B. | en_US |
dc.contributor.author | Nguyen V. | en_US |
dc.contributor.author | Hannoufa A. | en_US |
dc.contributor.author | Marsolais F. | en_US |
dc.contributor.author | Yuan Z.-C. | en_US |
dc.contributor.author | Yu K. | en_US |
dc.contributor.author | Austin R.S. | en_US |
dc.contributor.author | Liu J. | en_US |
dc.contributor.author | Kohalmi S.E. | en_US |
dc.contributor.author | Wu K. | en_US |
dc.contributor.author | Huang S. | en_US |
dc.contributor.author | Cui Y. | en_US |
dc.creator | Cui Y.;Huang S.;Wu K.;Kohalmi S.E.;Liu J.;Austin R.S.;Yu K.;Yuan Z.-C.;Marsolais F.;Hannoufa A.;Nguyen V.;Saatian B.;Kambhampati S.;Tian G.;Renaud J.;Wang Y.;Li C.;Chen C. | - |
dc.date.accessioned | 2019-07-17T04:20:42Z | - |
dc.date.available | 2019-07-17T04:20:42Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 20550278 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/414212 | - |
dc.description.abstract | Acetyl-coenzyme A (acetyl-CoA) is a central metabolite and the acetyl source for protein acetylation, particularly histone acetylation that promotes gene expression. However, the effect of acetyl-CoA levels on histone acetylation status in plants remains unknown. Here, we show that malfunctioned cytosolic acetyl-CoA carboxylase1 (ACC1) in Arabidopsis leads to elevated levels of acetyl-CoA and promotes histone hyperacetylation predominantly at lysine 27 of histone H3 (H3K27). The increase of H3K27 acetylation (H3K27ac) is dependent on adenosine triphosphate (ATP)-citrate lyase which cleaves citrate to acetyl-CoA in the cytoplasm, and requires histone acetyltransferase GCN5. A comprehensive analysis of the transcriptome and metabolome in combination with the genome-wide H3K27ac profiles of acc1 mutants demonstrate the dynamic changes in H3K27ac, gene transcripts and metabolites occurring in the cell by the increased levels of acetyl-CoA. This study suggests that H3K27ac is an important link between cytosolic acetyl-CoA level and gene expression in response to the dynamic metabolic environments in plants. ? 2017 The Author(s). | - |
dc.language | English | - |
dc.relation.ispartof | Nature Plants | - |
dc.title | Cytosolic acetyl-CoA promotes histone acetylation predominantly at H3K27 in Arabidopsis | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1038/s41477-017-0023-7 | - |
dc.identifier.scopus | 2-s2.0-85029781529 | - |
dc.identifier.url | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85029781529&doi=10.1038%2fs41477-017-0023-7&partnerID=40&md5=7c2df3cd6fd35877e653045cee11e4e9 | - |
dc.relation.pages | 814-824 | - |
dc.relation.journalvolume | 3 | - |
dc.relation.journalissue | 10 | - |
item.openairetype | journal article | - |
item.fulltext | no fulltext | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
crisitem.author.dept | Plant Biology | - |
crisitem.author.dept | Life Science | - |
crisitem.author.dept | Ph. D. Program In Plant Biotechnology Development Of Industry-academia Cooperation | - |
crisitem.author.orcid | 0000-0002-5791-3594 | - |
crisitem.author.parentorg | College of Life Science | - |
crisitem.author.parentorg | College of Life Science | - |
crisitem.author.parentorg | College of Life Science | - |
顯示於: | 植物科學研究所 |
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