https://scholars.lib.ntu.edu.tw/handle/123456789/414299
標題: | Tissue-specific positive feedback requirements for production of type I interferon following virus infection | 作者: | Prakash, Arun Smith, Eric CHIEN-KUO LEE Levy, David E |
公開日期: | 13-五月-2005 | 出版社: | AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC | 卷: | 280 | 期: | 19 | 起(迄)頁: | 18651 | 來源出版物: | The Journal of biological chemistry | 摘要: | Type I interferon (IFN) is synthesized by most nucleated cells following viral infection. Robust IFN production in cell culture requires positive feedback expression of inducible signaling components, such as the transcription factor IRF7. However, the role of positive feedback and IRF7 in vivo may be more complex. We found that IFN produced locally in the respiratory tract of influenza virus-infected mice displayed characteristics of positive feedback, including Stat1-dependent induction of IRF7 and IFN gene expression. IRF7 expression was similarly stimulus-dependent in most tissues. However, lymphoid tissue constitutively expressed high levels of IRF7 in the absence of induction or positive feedback, and this expression was largely confined to plasmacytoid dendritic cells (DC). These cells rapidly produced large quantities of multiple IFN alpha species following viral infection without positive feedback, whereas other hematopoietic cells, including other DC subtypes, expressed little IRF7 and were poor IFN producers in the absence of positive feedback. These data reveal a dual mechanism for the regulation of IFN production by differential expression of IRF7, involving positive feedback at local sites of infection combined with robust systemic production by IRF7-expressing plasmacytoid DC. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-21444443078&doi=10.1074%2fjbc.M501289200&partnerID=40&md5=0f03ae50fd738d29e356b94c730c1689 https://scholars.lib.ntu.edu.tw/handle/123456789/414299 |
ISSN: | 0021-9258 | DOI: | 10.1074/jbc.M501289200 |
顯示於: | 免疫學研究所 |
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