https://scholars.lib.ntu.edu.tw/handle/123456789/414589
標題: | Gold lotion from citrus peel extract ameliorates imiquimod-induced psoriasis-like dermatitis in murine | 作者: | Chi-Chien Lin Jung-Ju Wu Yi-Gen Pan Ya-Hsuan Chao Fang-Chu Lin Ying-Ray Lee CHING-LIANG CHU |
關鍵字: | citrus peels; imiquimod; inflammation; plasmacytoid dendritic cell; psoriasis | 公開日期: | 2018 | 出版社: | Wiley | 卷: | 98 | 期: | 14 | 起(迄)頁: | 5509 | 來源出版物: | Journal of the Science of Food and Agriculture | 摘要: | © 2018 Society of Chemical Industry BACKGROUND: Gold lotion (GL), a natural mixed product made from the peels of six citrus fruits, has recently been identified as possessing anti-oxidative, anti-inflammatory, and immunomodulatory effects. GL has been used to protect skin against UV-induced damage, but its activity against psoriasis, a chronic autoimmune skin disease caused by dysregulation between immune cells and keratinocytes, is not known. We therefore evaluated the effect of GL on imiquimod (IMQ)-induced psoriasis-like inflammation in mice. RESULTS: GL treatment significantly attenuated IMQ-induced psoriasis-like symptoms in mice. The inflammatory cytokines upregulated by IMQ in skin lesions were also inhibited by feeding GL. In addition, GL treatment reduced the infiltration of CD4 + T cells/neutrophils in skin lesions and the percentage of IL-17-/IL-22-producing T cells in lymph nodes. Furthermore, GL impaired IMQ-induced type I interferon production by plasmacytoid dendritic cells (pDCs) in vitro. CONCLUSION: Our results indicate GL can act to suppress the initiation of psoriasis and strongly suggest that GL may have potential to be applied to the treatment of psoriasis. © 2018 Society of Chemical Industry. |
URI: | http://www.scopus.com/inward/record.url?eid=2-s2.0-85054076589&partnerID=MN8TOARS https://scholars.lib.ntu.edu.tw/handle/123456789/414589 |
ISSN: | 00225142 | DOI: | 44062004 10.1002/jsfa.9097 |
SDG/關鍵字: | aminoquinoline derivative; cytokine; imiquimod; plant extract; animal; Bagg albino mouse; chemically induced; chemistry; Citrus; cytology; dermatitis; drug effect; fruit; human; immunology; isolation and purification; keratinocyte; male; mouse; psoriasis; Aminoquinolines; Animals; Citrus; Cytokines; Dermatitis; Fruit; Humans; Keratinocytes; Male; Mice; Mice, Inbred BALB C; Plant Extracts; Psoriasis |
顯示於: | 免疫學研究所 |
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