https://scholars.lib.ntu.edu.tw/handle/123456789/414589
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Chi-Chien Lin | en_US |
dc.contributor.author | Jung-Ju Wu | en_US |
dc.contributor.author | Yi-Gen Pan | en_US |
dc.contributor.author | Ya-Hsuan Chao | en_US |
dc.contributor.author | Fang-Chu Lin | en_US |
dc.contributor.author | Ying-Ray Lee | en_US |
dc.contributor.author | CHING-LIANG CHU | en_US |
dc.creator | Chi-Chien Lin;Jung-Ju Wu;Yi-Gen Pan;Ya-Hsuan Chao;Fang-Chu Lin;Ying-Ray Lee;Ching-Liang Chu | - |
dc.date.accessioned | 2019-07-23T07:29:47Z | - |
dc.date.available | 2019-07-23T07:29:47Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 00225142 | - |
dc.identifier.uri | http://www.scopus.com/inward/record.url?eid=2-s2.0-85054076589&partnerID=MN8TOARS | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/414589 | - |
dc.description.abstract | © 2018 Society of Chemical Industry BACKGROUND: Gold lotion (GL), a natural mixed product made from the peels of six citrus fruits, has recently been identified as possessing anti-oxidative, anti-inflammatory, and immunomodulatory effects. GL has been used to protect skin against UV-induced damage, but its activity against psoriasis, a chronic autoimmune skin disease caused by dysregulation between immune cells and keratinocytes, is not known. We therefore evaluated the effect of GL on imiquimod (IMQ)-induced psoriasis-like inflammation in mice. RESULTS: GL treatment significantly attenuated IMQ-induced psoriasis-like symptoms in mice. The inflammatory cytokines upregulated by IMQ in skin lesions were also inhibited by feeding GL. In addition, GL treatment reduced the infiltration of CD4 + T cells/neutrophils in skin lesions and the percentage of IL-17-/IL-22-producing T cells in lymph nodes. Furthermore, GL impaired IMQ-induced type I interferon production by plasmacytoid dendritic cells (pDCs) in vitro. CONCLUSION: Our results indicate GL can act to suppress the initiation of psoriasis and strongly suggest that GL may have potential to be applied to the treatment of psoriasis. © 2018 Society of Chemical Industry. | en_US |
dc.publisher | Wiley | en_US |
dc.relation.ispartof | Journal of the Science of Food and Agriculture | en_US |
dc.subject | citrus peels; imiquimod; inflammation; plasmacytoid dendritic cell; psoriasis | en_US |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | aminoquinoline derivative; cytokine; imiquimod; plant extract; animal; Bagg albino mouse; chemically induced; chemistry; Citrus; cytology; dermatitis; drug effect; fruit; human; immunology; isolation and purification; keratinocyte; male; mouse; psoriasis; Aminoquinolines; Animals; Citrus; Cytokines; Dermatitis; Fruit; Humans; Keratinocytes; Male; Mice; Mice, Inbred BALB C; Plant Extracts; Psoriasis | - |
dc.title | Gold lotion from citrus peel extract ameliorates imiquimod-induced psoriasis-like dermatitis in murine | en_US |
dc.identifier.doi | 44062004 | - |
dc.identifier.doi | 10.1002/jsfa.9097 | - |
dc.identifier.pmid | 29691866 | - |
dc.identifier.scopus | 2-s2.0-85054076589 | - |
dc.identifier.isi | WOS:000445851500042 | - |
dc.identifier.url | https://doi.org/10.1002/jsfa.9097 | - |
dc.relation.pages | 5509 | en_US |
dc.relation.journalvolume | 98 | en_US |
dc.relation.journalissue | 14 | en_US |
dc.identifier.external | 44062004 | - |
dc.relation.pageend | 5517 | en_US |
item.grantfulltext | none | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Immunology | - |
crisitem.author.orcid | 0000-0002-8463-526X | - |
crisitem.author.parentorg | College of Medicine | - |
顯示於: | 免疫學研究所 |
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