https://scholars.lib.ntu.edu.tw/handle/123456789/414615
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Lai, Y G | en_US |
dc.contributor.author | Gelfanov, V | en_US |
dc.contributor.author | Gelfanova, V | en_US |
dc.contributor.author | Kulik, L | en_US |
dc.contributor.author | CHING-LIANG CHU | en_US |
dc.contributor.author | Jeng, S W | en_US |
dc.contributor.author | Liao, N S | en_US |
dc.creator | Lai, Y G;Gelfanov, V;Gelfanova, V;Kulik, L;Ching-Liang Chu;Jeng, S W;Liao, N S | - |
dc.date.accessioned | 2019-07-23T08:55:25Z | - |
dc.date.available | 2019-07-23T08:55:25Z | - |
dc.date.issued | 1999-12-01 | - |
dc.identifier.issn | 0022-1767 | - |
dc.identifier.uri | http://www.scopus.com/inward/record.url?eid=2-s2.0-0033485915&partnerID=MN8TOARS | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/414615 | - |
dc.description.abstract | CD8 single-positive cells, including CD8alphaalpha+ and CD8alphabeta+ subsets, constitute the majority of TCRalphabeta+ intestinal intraepithelial lymphocytes (alphabeta iIEL) in mice. CD8+ alphabeta iIEL show significantly weaker responses to TCR stimulation in the presence of exogenous IL-2 than do CD8+ T cells of the central immune system. IL-15 is a T cell growth factor likely expressed in the intestine mucosa. To understand the role of IL-15 in CD8+ alphabeta iIEL biology, we compared the effects of exogenous IL-15 and IL-2 on the survival and primary responses of the two CD8+ alphabeta iIEL subsets in vitro. In contrast to the death of approximately 60% of both CD8alphaalpha+ and CD8alphabeta+ iIEL cultured in IL-2 with or without TCR stimulation, IL-15 promoted survival of the CD8alphaalpha+ subset in the presence of TCR stimulation and promoted survival of both subsets in the absence of TCR stimulation. The higher proliferation level of TCR stimulated CD8alphaalpha+ alphabeta iIEL cultured in IL-15 compared with those cultured in IL-2 is likely due to IL-15's prosurvival effects. In addition, unlike exogenous IL-2, exogenous IL-15 did not support the effector functions of either iIEL subsets, including IFN-gamma production, IL-4-induced Th2 cytokine production, and anti-TCR mAb-redirected cytotoxicity. These findings demonstrate that IL-15 and IL-2 are functionally distinct and suggest that IL-15 plays a unique role in the maintenance of the CD8+ alphabeta iIEL pool in the absence of Ag stimulation and in the survival and expansion of CD8alphaalpha+ alphabeta iIEL upon Ag stimulation. | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Journal of Immunology | en_US |
dc.title | IL-15 promotes survival but not effector function differentiation of CD8+ TCRalphabeta+ intestinal intraepithelial lymphocytes | en_US |
dc.type | journal article | en |
dc.identifier.pmid | 10570268 | - |
dc.identifier.scopus | 2-s2.0-0033485915 | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/0033485915 | - |
dc.relation.journalvolume | 163 | en_US |
dc.relation.journalissue | 11 | en_US |
dc.relation.pageend | 5850 | en_US |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.languageiso639-1 | en | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Immunology | - |
crisitem.author.orcid | 0000-0002-8463-526X | - |
crisitem.author.parentorg | College of Medicine | - |
顯示於: | 免疫學研究所 |
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