|Title:||Regulation of CD1 function and NK1.1<sup>+</sup> T cell selection and maturation by cathepsin S||Authors:||Riese, Richard J.
Shi, Guo Ping
Lennon-Dumenil, Ana Maria
Behar, Samuel M.
Chapman, Harold A.
|Issue Date:||1-Jan-2001||Journal Volume:||15||Journal Issue:||6||Source:||Immunity||Abstract:||
NK1.1+ T cells develop and function through interactions with cell surface CD1 complexes. In I-Ab mice lacking the invariant chain (Ii) processing enzyme, cathepsin S, NK1.1+ T cell selection and function are impaired. In vitro, thymic dendritic cells (DCs) from cathepsin S-/- mice exhibit defective presentation of the CD1-restricted antigen, α-galactosylceramide (α-GalCer). CD1 dysfunction is secondary to defective trafficking of CD1, which colocalizes with Ii fragments and accumulates within endocytic compartments of cathepsin S-/- DCs. I-Ak, cathepsin S-/- mice do not accumulate class II-associated Ii fragments and accordingly do not display CD1 abnormalities. Thus, function of CD1 is critically linked to processing of Ii, revealing MHC class II haplotype and cathepsin S activity as regulators of NK T cells.
|Appears in Collections:||免疫學研究所|
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