|Title:||Effects of radiotherapy on salivary gland function in patients with head and neck cancers||Authors:||Lin, CY
|Keywords:||buffering capacity; dental plaque; head and neck cancer; radiotherapy; saliva||Issue Date:||2015||Publisher:||ELSEVIER TAIWAN||Journal Volume:||10||Journal Issue:||3||Start page/Pages:||253||Source:||JOURNAL OF DENTAL SCIENCES||Abstract:||
© 2015, Association for Dental Sciences of the Republic of China. Published by Elsevier Taiwan LLC. All rights reserved. Background/purpose We explored changes in salivary gland function of head-and-neck cancer patients after radiotherapy, including pH of saliva, stimulated salivary flow rate, and saliva buffering capacity. The pH of saliva included that of parotid gland, submaxillary gland, and total resting saliva. We also investigated whether the acidity of dental plaque lowered pH of saliva. Materials and methods From a total of 62 patients, 11 had repeated measurements taken before and every month after radiotherapy. The remaining 51 patients had a single measurement taken after radiotherapy. Seven normal patients served as the control group. Results In the repeated measurement group, all examinations decreased dramatically in the 1st month after radiotherapy (P < 0.0001), and recovered from the 3rd month to the 6th month, but the flow rate could not return to pretreatment level. In the single measurement group, unilabiate linear regression analysis showed that the time-period after radiotherapy was a significant predictor influencing the pH of the submaxillary gland and total resting saliva. Pearson correlation coefficient analysis showed that the pH of dental plaque had a positive linear correlation with that of saliva. Concerning the influence of time-period, within 1 year after radiotherapy, all examinations were dropped. After 1 year the pH of resting saliva and plaque began to increase over time. The stimulated flow rate, pH of stimulated saliva, and buffering capacity, dropped < 1 year after radiotherapy group, increased 1-5 years after radiotherapy group, but dropped again > 5 years after radiotherapy group. Conclusion Our results indicated that oral hygiene care is important especially during the early period after radiotherapy.
|Appears in Collections:||免疫學研究所|
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