https://scholars.lib.ntu.edu.tw/handle/123456789/415243
標題: | Neutrophil Extracellular Traps Enhance Staphylococcus Aureus Vegetation Formation through Interaction with Platelets in Infective Endocarditis | 作者: | Hsu, Chih-Chieh RON-BIN HSU Ohniwa, Ryosuke L JENG-WEI CHEN CHANG-TSU YUAN JEAN-SAN CHIA Jung, Chiau-Jing |
關鍵字: | infective endocarditis; staphylococcus aureus; neutrophil extracellular traps; platelets; DNase I | 公開日期: | 五月-2019 | 出版社: | GEORG THIEME VERLAG KG | 卷: | 119 | 期: | 5 | 起(迄)頁: | 786 | 來源出版物: | Thrombosis and haemostasis | 摘要: | The mechanisms or host factors involved in septic thrombus or vegetation formation in Staphylococcus aureus-induced infective endocarditis (IE) are unclear. Using an experimental endocarditis rat model, here we demonstrated that S. aureus HG001-induced vegetation was composed of bacterial floes encased in aggregated platelets and surrounded by neutrophil extracellular traps (NETs). In vitro data demonstrated that platelets contribute to both biofilm and NET formation. Prophylactic administration of DNase I significantly reduced the size of vegetation induced by methicillin-resistant S. aureus (MRSA) and methicillin-sensitive S. aureus (MSSA) strains, even though MRSA and MSSA isolates express different biofilm phenotypes and NET-induction abilities in the presence of platelets. Moreover, delivery of both DNase I and daptomycin prophylactically and therapeutically produced synergistic effects by reducing vegetation size and bacterial numbers on damaged valve tissues in MRSA-induced IE. Together, these data suggest that NETs contribute to vegetation formation in S. aureus endocarditis and DNase I has the potential to control S. aureus-induced IE in the clinic. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85065159256&doi=10.1055%2fs-0039-1678665&partnerID=40&md5=60bc0d548d34ecba5791bbc5e48c701f https://scholars.lib.ntu.edu.tw/handle/123456789/415243 |
ISSN: | 0340-6245 | DOI: | 10.1055/s-0039-1678665 |
顯示於: | 免疫學研究所 |
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