https://scholars.lib.ntu.edu.tw/handle/123456789/415252
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Ma C.-H. | en_US |
dc.contributor.author | SHU-SEN CHANG | en_US |
dc.contributor.author | Tsai H.-J. | en_US |
dc.contributor.author | SUSAN SHUR-FEN GAU | en_US |
dc.contributor.author | I-MING CHEN | en_US |
dc.contributor.author | Shih-Cheng Liao | en_US |
dc.contributor.author | YI-LING CHIEN | en_US |
dc.contributor.author | MING-HSIEN HSIEH | en_US |
dc.contributor.author | CHI-SHIN WU | en_US |
dc.creator | Ma C.-H.;Shu-Sen Chang;Tsai H.-J.;Gau S.S.-F.;Chen I.-M.;Liao S.-C.;Chien Y.-L.;Hsieh M.H.;Wu C.-S. | - |
dc.date.accessioned | 2019-07-25T04:00:13Z | - |
dc.date.available | 2019-07-25T04:00:13Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 0001690X | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85041738392&doi=10.1111%2facps.12857&partnerID=40&md5=94b1fe46489099587a26def4591d085b | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/415252 | - |
dc.description.abstract | Objective: To investigate the association of different antipsychotic treatments with hospitalization due to self-harm among patients with schizophrenia. Method: This retrospective cohort study was based on Taiwan's universal health insurance database. Patients aged 15–45 years with a newly diagnosed schizophrenic disorder in 2001–2012 were included. The study outcome was the first hospitalization due to self-harm or undetermined injury after the diagnosis of schizophrenic disorders. The exposure status of antipsychotics was modeled as a time-dependent variable. The analyses were stratified by antipsychotic dosage based on defined daily dose (DDD). Results: Among 70 380 patients with a follow-up of 500 355 person-years, 2272 self-harm hospitalization episodes were identified. Compared with none or former use, current use of several second-generation antipsychotics with a dose of one DDD or above, including amisulpride, aripiprazole, clozapine, risperidone, and sulpiride, was associated with decreased risk of self-harm hospitalization, with clozapine showing the strongest effect (adjusted rate ratio = 0.26, 95% confidence interval 0.15–0.47). Conclusion: The protective effect on self-harm may vary across different antipsychotics. Further studies are needed to replicate the findings. ? 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd | - |
dc.publisher | Blackwell Publishing Ltd | - |
dc.relation.ispartof | Acta Psychiatrica Scandinavica | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | amisulpride; anticonvulsive agent; antidepressant agent; aripiprazole; benzodiazepine; chlorpromazine; clotiapine; clozapine; flupentixol; haloperidol; lithium; mood stabilizer; neuroleptic agent; olanzapine; quetiapine; risperidone; sulpiride; zotepine; clozapine; neuroleptic agent; adolescent; adult; Article; automutilation; cohort analysis; comparative study; drug efficacy; female; follow up; hospitalization; human; incidence; major clinical study; male; priority journal; retrospective study; risk factor; schizophrenia; automutilation; middle aged; public health; risk; schizophrenia; statistics and numerical data; Taiwan; young adult; Adolescent; Adult; Antipsychotic Agents; Clozapine; Female; Follow-Up Studies; Hospitalization; Humans; Male; Middle Aged; National Health Programs; Risk; Schizophrenia; Self-Injurious Behavior; Taiwan; Young Adult | - |
dc.title | Comparative effect of antipsychotics on risk of self-harm among patients with schizophrenia | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1111/acps.12857 | - |
dc.identifier.pmid | 29430641 | - |
dc.identifier.scopus | 2-s2.0-85041738392 | - |
dc.relation.pages | 296-305 | - |
dc.relation.journalvolume | 137 | - |
dc.relation.journalissue | 4 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Health Behaviors and Community Sciences | - |
crisitem.author.dept | Public Health | - |
crisitem.author.dept | Psychiatry | - |
crisitem.author.dept | Brain and Mind Sciences | - |
crisitem.author.dept | Psychiatry-NTUH | - |
crisitem.author.dept | Psychiatry-NTUH | - |
crisitem.author.dept | Psychiatry | - |
crisitem.author.dept | Psychiatry | - |
crisitem.author.dept | Psychiatry-NTUH | - |
crisitem.author.dept | Psychiatry-NTUHHC | - |
crisitem.author.dept | Psychiatry | - |
crisitem.author.dept | Psychiatry-NTUH | - |
crisitem.author.dept | Center for Artificial Intelligence and Advanced Robotics | - |
crisitem.author.dept | Psychiatry | - |
crisitem.author.dept | Psychiatry-NTUH | - |
crisitem.author.dept | Psychiatry | - |
crisitem.author.orcid | 0000-0001-5012-1132 | - |
crisitem.author.orcid | 0000-0002-2718-8221 | - |
crisitem.author.orcid | 0000-0001-7759-6648 | - |
crisitem.author.orcid | 0000-0003-4129-0879 | - |
crisitem.author.orcid | 0000-0002-3477-3015 | - |
crisitem.author.orcid | 0000-0002-3585-7843 | - |
crisitem.author.orcid | 0000-0003-2762-7295 | - |
crisitem.author.parentorg | College of Public Health | - |
crisitem.author.parentorg | College of Public Health | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | NTU Hsin-Chu Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | Others: University-Level Research Centers | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
顯示於: | 健康行為與社區科學研究所 |
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