https://scholars.lib.ntu.edu.tw/handle/123456789/415319
標題: | Prenatal perfluorooctanoic acid exposure is associated with early onset atopic dermatitis in 5-year-old children | 作者: | HSIAO-YU YANG Pau-Chung CHEN Chuang Y.-C. PAU-CHUNG CHEN Yue Leon Guo |
公開日期: | 2019 | 出版社: | Elsevier Ltd | 起(迄)頁: | 25-31 | 來源出版物: | Chemosphere | 摘要: | Atopic dermatitis (AD) is the most common childhood skin disease and the first step of atopic march. Perfluoroalkyl substance (PFAS) exposure is associated with atopic diseases, including AD. However, whether PFAS exposure is related to earlier AD onset remains unclear. We aimed to investigate the association between prenatal PFAS exposure and earlier onset of AD in children in a 5-year follow-up study. From 2001 to 2005, 1264 mother-infant pairs were recruited from eight Taiwanese maternity hospitals. PFAS levels were analyzed from cord blood. Information on children's health status, including AD occurrence, was obtained via phone interviews at multiple time points. Perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) concentrations were measured by ultra-high performance liquid chromatography/tandem mass spectrometry. Cox proportional hazards models assessed associations between prenatal PFAS exposure and early onset AD. Overall, 863 mother–infant pairs with complete measurements were recruited. The prevalence of physician-diagnosed AD before 5 years of age was 7.1%. PFOA and PFOS concentrations were grouped based on whether they were above the 75th percentile. PFOA exposure was positively associated with earlier onset of AD (Kaplan-Meier estimate, p = 0.014). In the Cox model, after adjusting for sex, family income, parental atopy, breast feeding, and maternal age at childbirth, significance was observed in children above the upper quartile (?75th) of the PFOA group (hazard ratio: 1.89; 95% confidence interval, 1.10–3.16). Our findings suggested that children with higher prenatal PFOA exposure have a higher risk of earlier AD development. Minimizing early life PFAS exposure may help inhibit AD development. ? 2019 Elsevier Ltd |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85066068267&doi=10.1016%2fj.chemosphere.2019.05.100&partnerID=40&md5=41812327ee48a3a161446ace46abb676 https://scholars.lib.ntu.edu.tw/handle/123456789/415319 |
ISSN: | 456535 | DOI: | 10.1016/j.chemosphere.2019.05.100 | SDG/關鍵字: | High performance liquid chromatography; Mass spectrometry; Atopic dermatitis; Birth cohort; Cox proportional hazards models; Perfluoroalkyl substances; Perfluorooctane sulfonates; Perfluorooctanoic acid; Survival curves; Ultra-high performance liquid chromatography/tandem mass spectrometries; Hazards; perfluorooctanoic acid; alkanesulfonic acid; fluorocarbon; octanoic acid derivative; perfluorooctanesulfonic acid; perfluorooctanoic acid; age structure; blood; chemical compound; child health; cohort analysis; detection method; maternal health; pollution exposure; skin; skin disorder; sulfonate; adult; Article; atopic dermatitis; atopy; breast feeding; child; childbirth; cohort analysis; controlled study; drug blood level; family income; female; follow up; high risk patient; human; infant; liquid chromatography-mass spectrometry; major clinical study; male; maternal age; mother child relation; multicenter study; onset age; prenatal exposure; prospective study; reversed phase ultra performance liquid chromatography; sex; structured questionnaire; Taiwanese; umbilical cord blood; atopic dermatitis; chemically induced; chemistry; child health; eczema; fetus blood; high performance liquid chromatography; mother; pregnancy; prenatal exposure; preschool child; Taiwan; Taiwan; Adult; Alkanesulfonic Acids; Breast Feeding; Caprylates; Child; Child Health; Child, Preschool; Chromatography, High Pressure Liquid; Dermatitis, Atopic; Eczema; Female; Fetal Blood; Fluorocarbons; Follow-Up Studies; Humans; Infant; Male; Maternal Age; Mothers; Pregnancy; Prenatal Exposure Delayed Effects; Taiwan |
顯示於: | 環境與職業健康科學研究所 |
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