https://scholars.lib.ntu.edu.tw/handle/123456789/415407
Title: | Particle toxicology and health - where are we? | Authors: | Shih, Chi-Hsiang Chen, Jen-Kun Kuo, Li-Wei Cho, Kuan-Hung TA-CHIH HSIAO Lin, Zhe-Wei Lin, Yi-Syuan Kang, Jiunn-Horng Lo, Yu-Chun Chuang, Kai-Jen TSUN-JEN CHENG Chuang, Hsiao-Chi Umezawa M. Handy R. Gulumian M. Tinkle S. Cassee F. |
Issue Date: | Apr-2019 | Publisher: | BMC | Journal Volume: | 16 | Journal Issue: | 1 | Source: | Particle and fibre toxicology | Abstract: | Particles and fibres affect human health as a function of their properties such as chemical composition, size and shape but also depending on complex interactions in an organism that occur at various levels between particle uptake and target organ responses. While particulate pollution is one of the leading contributors to the global burden of disease, particles are also increasingly used for medical purposes. Over the past decades we have gained considerable experience in how particle properties and particle-bio interactions are linked to human health. This insight is useful for improved risk management in the case of unwanted health effects but also for developing novel medical therapies. The concepts that help us better understand particles' and fibres' risks include the fate of particles in the body; exposure, dosimetry and dose-metrics and the 5 Bs: bioavailability, biopersistence, bioprocessing, biomodification and bioclearance of (nano)particles. This includes the role of the biomolecule corona, immunity and systemic responses, non-specific effects in the lungs and other body parts, particle effects and the developing body, and the link from the natural environment to human health. The importance of these different concepts for the human health risk depends not only on the properties of the particles and fibres, but is also strongly influenced by production, use and disposal scenarios. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/415407 | ISSN: | 1743-8977 | DOI: | https://api.elsevier.com/content/abstract/scopus_id/85064847188 10.1186/s12989-019-0302-8 |
SDG/Keyword: | asbestos; coal; nanoparticle; silicic acid; mineral fiber; nanoparticle; bioaccumulation; biosphere; chemical composition; disease burden; dosimetry; environmental exposure; health hazard; human; molecular interaction; nanotoxicology; nonhuman; particle size; particle toxicology; physical development; pneumoconiosis; priority journal; Review; risk assessment; risk management; toxicology; adverse event; air pollutant; chemistry; exposure; particulate matter; surface property; toxicity; Air Pollutants; Humans; Inhalation Exposure; Mineral Fibers; Nanoparticles; Particle Size; Particulate Matter; Risk Assessment; Risk Management; Surface Properties |
Appears in Collections: | 環境與職業健康科學研究所 |
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