|Title:||TRAIL-Mediated Suppression of T Cell Receptor Signaling Inhibits T Cell Activation and Inflammation in Experimental Autoimmune Encephalomyelitis||Authors:||Chyuan, I-Tsu
|Keywords:||T cell activation; T cell receptor signaling; TRAIL; apoptosis; experimental autoimmune encephalomyelitis||Issue Date:||2018||Publisher:||FRONTIERS MEDIA SA||Journal Volume:||9||Journal Issue:||JAN||Source:||Frontiers in immunology||Abstract:||
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces cell apoptosis by transducing apoptosis signals after interacting with its receptor (TRAIL-R). Although the actual biological role of TRAIL remains to be elucidated, recent accumulating evidence implies that TRAIL regulates immune responses and immune cell homeostasis via an apoptosis-independent pathway, suggesting a novel immune-regulatory role of TRAIL in autoimmune diseases. The purpose of this study is to address the immune-regulatory role and molecular mechanism of TRAIL in regulating T cell activation in autoimmune diseases.
|Appears in Collections:||免疫學研究所|
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