https://scholars.lib.ntu.edu.tw/handle/123456789/416261
標題: | Role of Ets-1 phosphorylation in the effector function of Th cells | 作者: | Grenningloh, Roland SHI-CHUEN MIAW Moisan, Jacques Graves, Barbara J Ho, I-Cheng |
關鍵字: | Ets-1; helper T cells; phosphorylation | 公開日期: | 六月-2008 | 出版社: | WILEY | 卷: | 38 | 期: | 6 | 起(迄)頁: | 1700 | 來源出版物: | European journal of immunology | 摘要: | The transcription factor Ets-1 critically regulates differentiation and function of T helper (Th) cells. In vitro studies have demonstrated that DNA binding and transcriptional activity of Ets-1 are regulated by phosphorylation. Depending on the site of phosphorylation, Ets-1 function can either be increased or inhibited. In addition, a splice variant lacking several inhibitory phosphorylation sites has been identified, raising the possibility that this splice variant may function differently from the full-length Ets-1. However, it is unclear how the activating and inhibitory phosphorylation events of Ets-1 are coordinated during Th cell activation. Furthermore, the biological consequences of Ets-1 phosphorylation and alternative splicing in regulating the function of Th cells are unknown. We report here that both activating and inhibitory phosphorylation events of Ets-1 occur simultaneously and independently of each other during Th cell activation. We further demonstrate that the effect of Ets-1 phosphorylation is very modest and that full-length Ets-1 and its splice variant are functionally interchangeable in the regulation of cytokine production in Th cells. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-49649104975&doi=10.1002%2feji.200738112&partnerID=40&md5=78dc07894022d88b7cbb070df71da333 https://scholars.lib.ntu.edu.tw/handle/123456789/416261 |
ISSN: | 0014-2980 | DOI: | 10.1002/eji.200738112 |
顯示於: | 免疫學研究所 |
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