https://scholars.lib.ntu.edu.tw/handle/123456789/416520
標題: | Translational Intracerebral Hemorrhage: a Need for Transparent Descriptions of Fresh Tissue Sampling and Preclinical Model Quality | 作者: | Che-Feng Chang Cai, L. Wang, J. |
關鍵字: | Preclinical criteria; Translational stroke research; Intracerebral hemorrhage; Hematoma; Multidisciplinary collaboration; Basic science | 公開日期: | 2015 | 出版社: | SPRINGER | 卷: | 6 | 期: | 5 | 起(迄)頁: | 384 | 來源出版物: | Translational Stroke Research | 摘要: | For years, strategies have been proposed to improve translational success in stroke research by improving the quality of animal studies. However, articles that report preclinical intracerebral hemorrhage (ICH) studies continue to lack adequate qualitative and quantitative descriptions of fresh brain tissue collection. They also tend to lack transparency about animal model quality. We conducted a systematic review of 82 ICH research articles to determine the level of detail reported for brain tissue collection. We found that only 24 (29 %) reported the volume, weight, or thickness of tissue collected and a specific description of the anatomical location. Thus, up to 71 % of preclinical ICH research articles did not properly define how fresh specimens were collected for biochemical measurements. Such omissions may impede reproducibility of results between laboratories. Although existing criteria have improved the quality of preclinical stroke studies, ICH researchers need to identify specific guidelines and strategies to avoid pitfalls, minimize bias, and increase reproducibility in this field. |
ISSN: | 1868-4483 1868-601X |
DOI: | 10.1007/s12975-015-0399-5 |
顯示於: | 生理學科所 |
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