|Title:||Hypoxia-induced Slug SUMOylation enhances lung cancer metastasis 11 Medical and Health Sciences 1112 Oncology and Carcinogenesis 06 Biological Sciences 0601 Biochemistry and Cell Biology||Authors:||Hung, Pei-Fang
|Keywords:||Hypoxia; Lung cancer; Metastasis; SUMOylation; Slug||Issue Date:||6-Jan-2019||Publisher:||BMC||Source:||Journal of experimental & clinical cancer research : CR||Journal Volume:||38||Journal Issue:||1||Abstract:||
The Slug-E-cadherin axis plays a critical role in non-small-cell lung cancers (NSCLCs) where aberrant upregulation of Slug promotes cancer metastasis. Now, the post-translational modifications of Slug and their regulation mechanisms still remain unclear in lung cancer. Hence, exploring the protein linkage map of Slug is of great interest for investigating the scenario of how Slug protein is regulated in lung cancer metastasis.
|Appears in Collections:||生物化學暨分子生物學科研究所|
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