https://scholars.lib.ntu.edu.tw/handle/123456789/416800
標題: | Genetic control of nucleolar size: An evolutionary perspective | 作者: | Ma, Tian-Hsiang Lee, Li-Wei Lee, Chi-Chang Yi, Yung-Hsiang SHIH-PENG CHAN Tan, Bertrand Chin-Ming Lo, Szecheng J |
關鍵字: | C. elegans; DAO-5/Nopp140/Nolc1; fibrillarin; genetic cascade; membrane-less organelle; ribosome biogenesis; translational suppression; tumor suppressor | 公開日期: | 25-四月-2016 | 出版社: | TAYLOR & FRANCIS INC | 卷: | 7 | 期: | 2 | 起(迄)頁: | 112 | 來源出版物: | Nucleus (Austin, Tex.) | 摘要: | Exploiting a C. elegans mutant (ncl-1) exhibiting nucleolar abnormalities, we recently identified the let-7/ncl-1/fib-1 genetic cascade underlying proper rRNA abundance and nucleolar size. These 3 factors, let-7 (a miRNA), NCL-1 (a member of the TRIM-NHL family), and fibrillarin (a nucleolar methyltransferase), are evolutionarily conserved across metazoans. In this article, we provide several lines of bioinformatic evidence showing that human and Drosophila homologues of C. elegans NCL-1, TRIM-71 and Brat, respectively, likely act as translational suppressors of fibrillarin. Moreover, since their 3'-UTRs contain putative target sites, they may also be under the control of the let-7 miRNA. We hypothesize that let-7, TRIM and fibrillarin contribute activities in concert, and constitute a conserved network controlling nucleolar size in eukaryotes. We provide an in-depth literature review of various molecular pathways, including the let-7/ncl-1/fib-1 genetic cascade, implicated in the regulation of nucleolar size. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84964626428&doi=10.1080%2f19491034.2016.1166322&partnerID=40&md5=722ede4ce65d46d4859f3d76c6d98e3e https://scholars.lib.ntu.edu.tw/handle/123456789/416800 |
ISSN: | 1949-1034 | DOI: | 10.1080/19491034.2016.1166322 |
顯示於: | 微生物學科所 |
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