Skip navigation
  • 中文
  • English

DSpace CRIS

  • DSpace logo
  • Home
  • Organizations
  • Researchers
  • Research Outputs
  • Explore by
    • Organizations
    • Researchers
    • Research Outputs
  • Academic & Publications
  • Sign in
  • 中文
  • English
  1. NTU Scholars
  2. 醫學院
  3. 微生物學科所
Please use this identifier to cite or link to this item: https://scholars.lib.ntu.edu.tw/handle/123456789/416950
DC FieldValueLanguage
dc.contributor.authorLiu D.-W.en_US
dc.contributor.authorYang Y.-C.en_US
dc.contributor.authorLin H.-F.en_US
dc.contributor.authorLin M.-F.en_US
dc.contributor.authorCheng Y.-W.en_US
dc.contributor.authorChu C.-N.en_US
dc.contributor.authorTsao Y.-P.en_US
dc.contributor.authorSHOW-LI CHENen_US
dc.creatorLiu D.-W.;Yang Y.-C.;Lin H.-F.;Lin M.-F.;Cheng Y.-W.;Chu C.-N.;Tsao Y.-P.;Show-Li Chen-
dc.date.accessioned2019-08-30T03:50:00Z-
dc.date.available2019-08-30T03:50:00Z-
dc.date.issued2007-
dc.identifier.issn0022-538X-
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-33947371281&doi=10.1128%2fJVI.02256-06&partnerID=40&md5=3fecd1f6d738572806500d2894b957c9-
dc.identifier.urihttps://scholars.lib.ntu.edu.tw/handle/123456789/416950-
dc.description.abstractPreviously, we found that human papillomavirus type 16 (HPV-16) E5 protein is a tamor rejection antigen and can induce cytotoxic T-lymphocyte (CTL) activity. Therefore, in this study, human leukocyte antigen A*0201 (HLA-A*0201)-restricted human CTL epitopes of HPV-16 E5 protein were identified using a bioinformatics approach, and the abilities of these predicted peptides to induce an immune response in HLA-A*0201 transgenic mice were confirmed by assaying E5-specific CTLs and in vitro-generated CTLs from normal peripheral blood T lymphocytes of HLA-A2-positive human donors. Second, the CTL responses to HLA-A*0201 CTL epitopes (E5 63-71 and E7 11-20) were examined in HPV-16-infected patients with HLA-A2. Third, the effect of HLA-A-type alleles on CTL activities in response to the entire E5 and E7 proteins was examined in cervical cancer patients. E5 and E7 peptides (but not the whole proteins) stimulated E5- and E7-specific CTL recall responses in HPV-16- and HLA-A2-positive cervical cancer patients, and HPV-16 E5 and E7 proteins stimulated na?ve T cells in HPV-16-megative cervical cancer patients with HLA-A11 and -A24 haplotypes. In summary, this is the first demonstration that E5 63-71 is an HLA-A*0201-restricted T-cell epitope of HPV-16 E5. Copyright ? 2007, American Society for Microbiology. All Rights Reserved.-
dc.language.isoen_US-
dc.relation.ispartofJournal of Virology-
dc.subject.otherHLA A0201 antigen; HLA antigen; protein E5; protein E7; tumor rejection antigen; unclassified drug; virus protein; adult; aged; allele; animal cell; article; controlled study; cytotoxic T lymphocyte; female; haplotype; human; human cell; Human papillomavirus type 16; immune response; mouse; nonhuman; priority journal; T lymphocyte; uterine cervix cancer; Adenoviridae; Adult; Aged; Alleles; Animals; Carcinoma; Epitopes; Female; HLA-A Antigens; Human papillomavirus 16; Humans; Interferon Type II; Mice; Mice, Transgenic; Middle Aged; Neoplasm Staging; Oncogene Proteins, Viral; T-Lymphocytes, Cytotoxic; Uterine Cervical Neoplasms; Human papillomavirus type 16; Mus musculus-
dc.subject.other[SDGs]SDG3-
dc.titleCytotoxic T-lymphocyte responses to human papillomavirus type 16 E5 and E7 proteins and HLA-A*0201-restricted T-cell peptides in cervical cancer patientsen_US
dc.typejournal article-
dc.identifier.doi10.1128/JVI.02256-06-
dc.identifier.pmid17202211-
dc.identifier.scopus2-s2.0-33947371281-
dc.relation.pages2869-2879-
dc.relation.journalvolume81-
dc.relation.journalissue6-
item.languageiso639-1en_US-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_6501-
item.openairetypejournal article-
item.fulltextno fulltext-
item.cerifentitytypePublications-
crisitem.author.deptMicrobiology-
crisitem.author.orcid0000-0002-6588-8632-
crisitem.author.parentorgCollege of Medicine-
Appears in Collections:微生物學科所
Show simple item record

SCOPUSTM   
Citations

23
checked on Mar 27, 2023

WEB OF SCIENCETM
Citations

20
checked on Mar 19, 2023

Page view(s)

45
checked on Apr 1, 2023

Google ScholarTM

Check

Altmetric

Altmetric

Related Items in TAIR


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of “NTU Repository” with “Academic Hub” to form NTU Scholars.

總館學科館員 (Main Library)
醫學圖書館學科館員 (Medical Library)
社會科學院辜振甫紀念圖書館學科館員 (Social Sciences Library)

開放取用是從使用者角度提升資訊取用性的社會運動,應用在學術研究上是透過將研究著作公開供使用者自由取閱,以促進學術傳播及因應期刊訂購費用逐年攀升。同時可加速研究發展、提升研究影響力,NTU Scholars即為本校的開放取用典藏(OA Archive)平台。(點選深入了解OA)

  • 請確認所上傳的全文是原創的內容,若該文件包含部分內容的版權非匯入者所有,或由第三方贊助與合作完成,請確認該版權所有者及第三方同意提供此授權。
    Please represent that the submission is your original work, and that you have the right to grant the rights to upload.
  • 若欲上傳已出版的全文電子檔,可使用Sherpa Romeo網站查詢,以確認出版單位之版權政策。
    Please use Sherpa Romeo to find a summary of permissions that are normally given as part of each publisher's copyright transfer agreement.
  • 網站簡介 (Quickstart Guide)
  • 使用手冊 (Instruction Manual)
  • 線上預約服務 (Booking Service)
  • 方案一:臺灣大學計算機中心帳號登入
    (With C&INC Email Account)
  • 方案二:ORCID帳號登入 (With ORCID)
  • 方案一:定期更新ORCID者,以ID匯入 (Search for identifier (ORCID))
  • 方案二:自行建檔 (Default mode Submission)
  • 方案三:學科館員協助匯入 (Email worklist to subject librarians)
Build with DSpace-CRIS - Extension maintained and optimized by Logo 4SCIENCE Feedback