https://scholars.lib.ntu.edu.tw/handle/123456789/417022
Title: | The interplay between Siglecs and sialylated pathogens | Authors: | YUNG-CHI CHANG Nizet, Victor |
Keywords: | Siglec; bacterial pathogenesis; innate immunity; molecular mimicry, sialic acid | Issue Date: | Sep-2014 | Publisher: | OXFORD UNIV PRESS INC | Journal Volume: | 24 | Journal Issue: | 9 | Start page/Pages: | 818 | Source: | Glycobiology | Abstract: | Siglecs are mammalian sialic acid (Sia) recognizing immunoglobulin-like receptors expressed across the major leukocyte lineages, and function to recognize ubiquitous Sia epitopes on cell surface glycoconjugates and regulate immunological and inflammatory activities of these cells. A large subset referred to as CD33-related Siglecs are inhibitory receptors that limit leukocyte activation, and recent research has shown that the pathogen group B Streptococcus (GBS) binds to these Siglecs in Sia- and protein-dependent fashion to downregulate leukocyte bactericidal capacity. Conversely, sialoadhesin is a macrophage phagocytic receptor that engages GBS and other sialylated pathogens to promote effective phagocytosis and antigen presentation for the adaptive immune response. A variety of other important Siglec interactions with bacterial, viral and protozoan pathogens are beginning to be recognized. Siglec genes and binding specificities are rapidly evolving among primates, with key extant polymorphisms in human populations that may influence susceptibility to infection-associated disorders including chronic obstructive pulmonary disease and premature birth. This review summarizes current understanding of interactions between pathogens and Siglecs, a field of investigation that is likely to continue expanding in scope and medical importance. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84905503889&doi=10.1093%2fglycob%2fcwu067&partnerID=40&md5=5416bd0942626bcbd30c840fc8bfb6af https://scholars.lib.ntu.edu.tw/handle/123456789/417022 |
ISSN: | 0959-6658 | DOI: | 10.1093/glycob/cwu067 |
Appears in Collections: | 微生物學科所 |
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