https://scholars.lib.ntu.edu.tw/handle/123456789/417107
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Lin Y.-C. | en_US |
dc.contributor.author | Peng J.-M. | en_US |
dc.contributor.author | WON-BO WANG | en_US |
dc.creator | Lin Y.-C.;Peng J.-M.;Won-Bo Wang | - |
dc.date.accessioned | 2019-09-02T06:52:06Z | - |
dc.date.available | 2019-09-02T06:52:06Z | - |
dc.date.issued | 2000 | - |
dc.identifier.issn | 0950-9232 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0034682327&doi=10.1038%2fsj.onc.1203582&partnerID=40&md5=b33b89820e47824a5425c83b32cbfe75 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/417107 | - |
dc.description.abstract | Overexpression of HER-2/neu (also known as c-erbB-2) proto-oncogene frequently occurs in many different types of human cancers, including ovarian carcinoma, and is known to enhance tumor metastasis and chemoresistance. Previous studies showed that inhibition of HER-2/neu expression by various agents, such as adenovirus E1A and simian virus 40 large T, can lead to suppression of tumorigenicity of HER-2/neu-overexpressing cancer cells. Here we report that T/t-common, which contains the N-terminal common domain of simian virus 40 large T and small t antigens, could specifically repress the HER-2/neu promoter. When the coding sequence of T/t-common was stably transfected into the HER-2/neu-overexpressing human ovarian carcinoma SK-OV-3 cells, the expression of HER-2/neu was dramatically reduced by the expression of T/t-common. Accordingly the tumorigenic potential of these T/t-common-expressing clones, including the ability to grow anchorage-independently and the ability to induce tumor in nu/nu mice, was also drastically suppressed. Furthermore, when T/t-common was transiently cotransfected with the activated genomic neu into NIH3T3 cells, the transforming activity of the latter was suppressed by T/t-common in soft-agarose microcolony formation assays. Taken together, these data suggest that T/t-common may act as a transformation suppressor of the HER-2/neu oncogene. | - |
dc.language.iso | en_US | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.ispartof | Oncogene | - |
dc.subject | HER-2/neu; Simian virus 40 (SV40); Small t antigen; T/t-common; Tumor suppressor | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | virus large T antigen; virus small T antigen; Adenovirus; amino terminal sequence; animal experiment; animal model; article; carcinogenicity; colony formation; controlled study; female; fibroblast; gene expression; genetic transformation; human; human cell; metastasis; mouse; nonhuman; oncogene neu; ovary carcinoma; priority journal; promoter region; Simian virus 40; Adenoviridae; Animalia; RNA viruses; Simiae; Simian virus; Simian virus 40 | - |
dc.title | The N-terminal common domain of simian virus 40 large T and small t antigens acts as a transformation suppressor of the HER-2/neu oncogene | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1038/sj.onc.1203582 | - |
dc.identifier.pmid | 10851070 | - |
dc.identifier.scopus | 2-s2.0-0034682327 | - |
dc.relation.pages | 2704-2713 | - |
dc.relation.journalvolume | 19 | - |
dc.relation.journalissue | 22 | - |
item.openairetype | journal article | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
item.languageiso639-1 | en_US | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Microbiology | - |
crisitem.author.orcid | 0000-0002-0135-8958 | - |
crisitem.author.parentorg | College of Medicine | - |
顯示於: | 微生物學科所 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。