https://scholars.lib.ntu.edu.tw/handle/123456789/417151
Title: | Synthesis of Neisseria meningitidis serogroup W135 capsular oligosaccharides for immunogenicity comparison and vaccine development | Authors: | Wang C.-H. Li S.-T. Lin T.-L. Cheng Y.-Y. Sun T.-H. JIN-TOWN WANG Cheng T.-J.R. Mong K.K.T. Wong C.-H. Wu C.-Y. |
Keywords: | bactericidal; N. meningitidis; oligosaccharides; total synthesis; vaccine | Issue Date: | 2013 | Journal Volume: | 52 | Journal Issue: | 35 | Start page/Pages: | 9157-9161 | Source: | Angewandte Chemie - International Edition | Abstract: | Sweetening the deal: N.meningitidis serogroup W135 capsular oligosaccharides were synthesized in lengths from disaccharides to decasaccharides. Sera from mice immunized with these oligosaccharide-protein conjugates were examined by a glycan microarray (see picture) and bactericidal assay for antibody specificity and the ability to kill bacteria. Copyright ? 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84883010128&doi=10.1002%2fanie.201302540&partnerID=40&md5=ab0cdc3d7380324fb19ffcaf8607199a https://scholars.lib.ntu.edu.tw/handle/123456789/417151 |
ISSN: | 1433-7851 | DOI: | 10.1002/anie.201302540 | SDG/Keyword: | bactericidal; Glycan microarrays; Immunogenicity; Meningitidis; Neisseria meningitidis; Total synthesis; Vaccine development; Vaccines; Oligosaccharides; oligosaccharide; recombinant vaccine; vaccine; article; bactericidal; chemical structure; chemistry; immunology; N. meningitidis; Neisseria meningitidis; synthesis; total synthesis; bactericidal; N. meningitidis; oligosaccharides; total synthesis; vaccine; Molecular Structure; Neisseria meningitidis, Serogroup W-135; Oligosaccharides; Vaccines, Synthetic |
Appears in Collections: | 微生物學科所 |
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