Synthesis of Neisseria meningitidis serogroup W135 capsular oligosaccharides for immunogenicity comparison and vaccine development
Journal
Angewandte Chemie - International Edition
Journal Volume
52
Journal Issue
35
Pages
9157-9161
Date Issued
2013
Author(s)
Wang C.-H.
Li S.-T.
Lin T.-L.
Cheng Y.-Y.
Sun T.-H.
Cheng T.-J.R.
Mong K.K.T.
Wong C.-H.
Wu C.-Y.
Abstract
Sweetening the deal: N.meningitidis serogroup W135 capsular oligosaccharides were synthesized in lengths from disaccharides to decasaccharides. Sera from mice immunized with these oligosaccharide-protein conjugates were examined by a glycan microarray (see picture) and bactericidal assay for antibody specificity and the ability to kill bacteria. Copyright ? 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Subjects
bactericidal; N. meningitidis; oligosaccharides; total synthesis; vaccine
SDGs
Other Subjects
bactericidal; Glycan microarrays; Immunogenicity; Meningitidis; Neisseria meningitidis; Total synthesis; Vaccine development; Vaccines; Oligosaccharides; oligosaccharide; recombinant vaccine; vaccine; article; bactericidal; chemical structure; chemistry; immunology; N. meningitidis; Neisseria meningitidis; synthesis; total synthesis; bactericidal; N. meningitidis; oligosaccharides; total synthesis; vaccine; Molecular Structure; Neisseria meningitidis, Serogroup W-135; Oligosaccharides; Vaccines, Synthetic
Type
journal article