https://scholars.lib.ntu.edu.tw/handle/123456789/417231
標題: | Identification of humoral antigenic determinants in the hepatitis C virus NS3 protein | 作者: | Hwang L.-H. PEI-MING YANG Lai M.-Y. BOR-LUEN CHIANG JIA-HORNG KAO Wang, Jin-Town Lee S.-Y. Chian H.-M. Chi W.-K. Chu Y.-D. PEI-JER CHEN DING-SHINN CHEN |
公開日期: | 1996 | 出版社: | Oxford University Press | 卷: | 174 | 期: | 1 | 起(迄)頁: | 173-176 | 來源出版物: | Journal of Infectious Diseases | 摘要: | Immunoblot analysis on serum samples from 90 patients with chronic hepatitis C virus infection revealed four putative immunogenic regions within the NS3 protein of the virus: E (around aa 1250/1251), A (within aa 1250- 1334), A/B (around aa 1323 and 1334), and B/C (around aa 1407 and 1412). Among them, region E was most immunodominant, and region A was recognized much less frequently by patients with cirrhosis than by those with chronic hepatitis (10% vs. 46%, χ2 = 12.05. P < .01). The results suggest that region A might be a potential prognostic marker to differentiate chronic hepatitis from cirrhosis. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84984564143&doi=10.1093%2finfdis%2f174.1.173&partnerID=40&md5=4efa74b666d710c36421f5cfd0c80616 https://scholars.lib.ntu.edu.tw/handle/123456789/417231 |
ISSN: | 0022-1899 | DOI: | 10.1093/infdis/174.1.173 | SDG/關鍵字: | virus antigen; virus protein; adult; antigen recognition; article; controlled study; hepatitis C; Hepatitis C virus; human; humoral immunity; immunoblotting; liver cirrhosis; major clinical study; priority journal; prognosis |
顯示於: | 微生物學科所 |
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