|Title:||Sonochemical synthesis and fabrication of honeycomb like zirconium dioxide with chitosan modified electrode for sensitive electrochemical determination of anti-tuberculosis (TB) drug||Authors:||Chen, Tse Wei
Soliman Elshikh, Mohamed
Chen, Shen Ming
Al Farraj, Dunia A.
Al Khulaifi, Manal M.
Alkufeidy, Roua M.
Sivasamy Vasantha, Airathevar
|Keywords:||Anti-tuberculosis drug analysis | Biopolymer | Electrochemical sensor | Sonochemical synthesis | Zirconium dioxide||Issue Date:||1-Dec-2019||Journal Volume:||59||Source:||Ultrasonics Sonochemistry||Abstract:||
© 2019 Elsevier B.V. Herein, novel honeycomb like zirconium dioxide with chitosan (ZrO2@chitosan) nanocomposite have been designed through a facile ultrasound-assisted method and followed by a simple sonication process (bath-type ultrasound washer; Honda Electronics-W-118T; 100 W/cm2 and 300 kHz frequency). After then, as-synthesized ZrO2@chitosan was characterized by FESEM, XRD and EIS. The ZrO2@chitosan nanocomposite modified glassy carbon electrode shows excellent electrochemical sensing performance towards anti-tuberculosis drug (rifampicin). Furthermore, the ZrO2@chitosan modified and fabricated electrochemical sensor showed a wide linear range between 0.015 µM and 547.4 µM and nanomolar detection limit (7.5 nM). Moreover, the ZrO2@chitosan modified electrode showed selectivity towards the detection of anti-tuberculosis drug (rifampicin). The ZrO2@chitosan nanocomposite film modified non-enzymatic sensor has high stable and good reproducible towards the detection of rifampicin. In addition, the as-synthesized ZrO2@chitosan nanocomposite modified electrode has been applied to the determination of rifampicin in biological samples such as human serum and urine samples.
|Appears in Collections:||政治學系|
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