|Title:||A novel electrochemical sensor for the detection of oxidative stress and cancer biomarker (4-nitroquinoline N-oxide) based on iron nitride nanoparticles with multilayer reduced graphene nanosheets modified electrode||Authors:||Ramalingam, R. Jothi
Chen, Shen Ming
Chen, Tse Wei
|Keywords:||4-nitroquinoline N-oxide | Biological samples | Cancer biomarker | Iron nitride | Reduced graphene oxide||Issue Date:||15-Jul-2019||Source:||Sensors and Actuators, B: Chemical||Abstract:||
© 2019 Elsevier B.V. Herein, a novel iron nitride nanoparticles (Fe2N NPs) decorated reduced graphene oxide (rGOS) nanocomposite have been designed through a solvothermal method and followed by a nitridation process. After then, as-synthesized Fe2N NPs@rGOS was characterized by HRTEM, FESEM, XPS, XRD, and EIS. Furthermore, the nanocomposite modified SPCE (screen-printed carbon electrode) shows excellent electrochemical sensing performance towards biomarker of 4-nitroquinoline N-oxide (4-NQO) with fast detection. 4-NQO is one of the important cancer biomarker. Moreover, the fabricated sensor showed a wide linear window for 4-NQO between 0.05–574.2 μM and nanomolar detection limit (9.24 nM). Further, the as-prepared Fe2N NPs@rGOS/SPCE has been applied to the determination of 4-NQO in human blood and urine samples with recoveries close to 100%.
|Appears in Collections:||政治學系|
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