|Title:||Functionalization of a carbon nanofiber with a tetrasulfonatophenyl ruthenium(II)porphine complex for real-time amperometric sensing of chlorpromazine||Authors:||Kubendhiran, Subbiramaniyan
Chen, Shen Ming
|Keywords:||Amperometry | Chlorpromazine hydrochloride | Electro-catalytic activity | Hollow-platelet | Supramolecular interaction||Issue Date:||1-May-2019||Journal Volume:||186||Journal Issue:||5||Source:||Microchimica Acta||Abstract:||
© 2019, Springer-Verlag GmbH Austria, part of Springer Nature. A carbon nanofiber functionalized with ruthenium(II)-tetrasulfonato phenyl porphine (CNF/Ru-TSPP) is shown to be viable sensor for amperometric determination of the antipsychotic drug chlorpromazine (CPZ). The hollow platelet structured Ru-TSPP combines with the hollow cylindrical tube-like structure of the CNF via π stacking interaction. The morphological and electro conductive properties of the electrode were characterized by spectrophotometric techniques. The CNF/Ru-TSPP modified electrode displays a large surface-to-volume ratio, good electron transport and good electrocatalytic activity. The amperometric sensor, typically operated at a potential 0.63 V (vs. Ag/AgCl) exhibits a linear response in the 0.6 nM to 1.1 mM CPZ concentration range, has a 0.2 nM detection limit, and a remarkably good electrochemical sensitivity (2.405 μA μM −1 cm −2 ). The sensor is selective, repeatable and reproducible. It was successfully applied to the determination of CPZ in spiked serum samples. [Figure not available: see fulltext.].
|Appears in Collections:||政治學系|
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