|Title:||EFFECT OF SILYMARIN ON LIPID AND ALCOHOL METABOLISM IN MICE FOLLOWING LONG-TERM ALCOHOL CONSUMPTION||Authors:||CHUNG-HSI CHOU
|Issue Date:||2012||Publisher:||WILEY-BLACKWELL||Journal Volume:||36||Journal Issue:||3||Start page/Pages:||369||Source:||JOURNAL OF FOOD BIOCHEMISTRY||Abstract:||
An alcoholic fatty liver disease was induced by feeding an ethanol diet. Eight mice per group were randomly assigned to each following group: (1) control liquid diet+0.5mL ddH 2 O; (2) control liquid diet+150mg silymarin/kg body weight (BW) in 0.5mL ddH 2 O; (3) ethanol liquid diet+0.5mL ddH 2 O; and (4) ethanol liquid diet+150mg silymarin/kg BW in 0.5mL ddH 2 O. The ethanol diet increased (P<0.05) liver size and total triglyceride levels but a gavage of silymarin reduced (P<0.05) them. Silymarin also decreased (P<0.05) aspartate aminotransferase (AST) value, the pathogenic hepatic lipid drop and cytoplasmic vacuolization formation in alcohol-fed mice, with respect to the regulation of lipogenesis and alcohol metabolism, although silymarin did not (P<0.05) influence 3-hydroxy-3-methylglutaryl-CoA reductase, sterol regulatory element-binding protein-1, acetyl-CoA carboxylase, fatty acid synthase, carnitine palmitoyltransferase 1A (CPT1A), alcohol dehydrogenase 1 and alcohol dehydrogenase 7 gene expressions. However, proliferator-activated receptor-alpha, cytochrome P450, family 1, subfamily e, polypeptide 1, cytochrome P450, family 1, subfamily a, polypeptide 1 and catalase were up-regulated in the livers of alcohol-fed mice with a gavage of silymarin. © 2011 Wiley Periodicals, Inc.
|Appears in Collections:||動物科學技術學系|
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