https://scholars.lib.ntu.edu.tw/handle/123456789/425204
Title: | Hepatoprotection of silymarin against thioacetamide-induced chronic liver fibrosis | Authors: | Chen, I-Shu YI-CHEN CHEN CHUNG-HSI CHOU Chuang, Ruei-Feng LEE-YAN SHEEN CHIH-HSIEN CHIU |
Keywords: | thioacetami de; chronic liverfibrosis; silymarin; MMP; TIMP families; hepatic stellate cell activation | Issue Date: | May-2012 | Publisher: | WILEY-BLACKWELL | Journal Volume: | 92 | Journal Issue: | 7 | Start page/Pages: | 1441 | Source: | Journal of the science of food and agriculture | Abstract: | Liver fibrosis is chronic liver damage usually caused by alcohol, viruses or other toxins and is characterised by an excessive accumulation of extracellular matrix proteins such as collagen. The aim of this study was to establish an animal model of chronic liver damage and investigate molecular mechanisms of silymarin hepatoprotective effects. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/425204 https://www.scopus.com/inward/record.uri?eid=2-s2.0-84859429176&doi=10.1002%2fjsfa.4723&partnerID=40&md5=88d5a5d70f32918285e50339b5b5c20c |
ISSN: | 00225142 | DOI: | 10.1002/jsfa.4723 | SDG/Keyword: | cholesterol; matrix metalloproteinase; plant extract; silymarin; thioacetamide; tissue inhibitor of metalloproteinase; transcription factor AP 1; transforming growth factor beta1; triacylglycerol; animal; article; blood; body weight; chemistry; chronic disease; disease model; down regulation; drug effect; experimental liver cirrhosis; Institute for Cancer Research mouse; liver; male; metabolism; mouse; organ size; pathology; phytotherapy; randomization; Silybum marianum; toxic hepatitis; Animals; Body Weight; Cholesterol; Chronic Disease; Disease Models, Animal; Down-Regulation; Drug-Induced Liver Injury; Liver; Liver Cirrhosis, Experimental; Male; Matrix Metalloproteinases; Mice; Mice, Inbred ICR; Milk Thistle; Organ Size; Phytotherapy; Plant Extracts; Random Allocation; Silymarin; Thioacetamide; Tissue Inhibitor of Metalloproteinases; Transcription Factor AP-1; Transforming Growth Factor beta1; Triglycerides; Animalia; Mus |
Appears in Collections: | 動物科學技術學系 |
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