https://scholars.lib.ntu.edu.tw/handle/123456789/425332
標題: | Taurine ameliorates alcoholic steatohepatitis via enhancing self-antioxidant capacity and alcohol metabolism | 作者: | Fang, Yi-Jen CHIH-HSIEN CHIU Chang, Yuan-Yen CHUNG-HSI CHOU Lin, Hui-Wen MING-FONG CHEN YI-CHEN CHEN |
關鍵字: | Alcoholic steatohepatitis; Antioxidant capacity; Alcohol metabolism; Liver lipids; Liver damage | 公開日期: | 2011 | 出版社: | ELSEVIER SCIENCE BV | 卷: | 44 | 期: | 9 | 起(迄)頁: | 3105 | 來源出版物: | Food Research International | 摘要: | Chronic alcohol consumption or alcohol abuse is the main cause of alcoholic steatohepatitis or further cirrhosis. This study was to exam if the antioxidant capacity and alcohol metabolism in livers of chronic alcohol-fed rats were improved by supplementing taurine (Tau). Rats were randomly divided into four groups with five times per week of treatment: 1) isocaloric solution; 2) 3. g. alcohol/kg. BW/day; 3) 3. g. alcohol/kg. BW/day. +. 1. g. taurine. (Tau)/kg. BW/day; and 4) 3. g. alcohol/kg. BW/day. +. 2. g Tau/kg. BW/day. A 6-week alcohol consumption resulted in lower (p< 0.05) body weight gain and self-antioxidant capacities, as well as increased (p< 0.05) liver size, serum/hepatic lipids, and AST and ALT values. However, alcohol-fed rats co-treated with Tau have decreased (p< 0.05) liver lipid levels via increasing fecal lipid output and cholesterol metabolism. Besides, co-treatment of Tau also enhanced (p< 0.05) self-antioxidant capacities and alcohol metabolism in livers via enhancing GSH contents, CAT, GSH-Px, ADH, and ALDH activities, but decreasing MDA contents. In a histological examination of rat liver, microvesicular steatosis and necrotic cells were observed in alcohol-fed rats without Tau while largely suppressed microvesicular steatosis and no necrotic cells were observed in alcohol-fed rat supplemented with Tau. Therefore, Tau could be an effective hepatoprotective agent against alcohol-induced damage via enhancing self-antioxidant capacity and alcohol metabolism. © 2011. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/425332 https://www.scopus.com/inward/record.uri?eid=2-s2.0-80054716144&doi=10.1016%2fj.foodres.2011.08.004&partnerID=40&md5=1499417a106172ad9ff23afa945d7790 |
ISSN: | 0963-9969 | DOI: | 10.1016/j.foodres.2011.08.004 |
顯示於: | 動物科學技術學系 |
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