https://scholars.lib.ntu.edu.tw/handle/123456789/425332
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Fang, Yi-Jen | en_US |
dc.contributor.author | CHIH-HSIEN CHIU | en_US |
dc.contributor.author | Chang, Yuan-Yen | en_US |
dc.contributor.author | CHUNG-HSI CHOU | en_US |
dc.contributor.author | Lin, Hui-Wen | en_US |
dc.contributor.author | MING-FONG CHEN | en_US |
dc.contributor.author | YI-CHEN CHEN | en_US |
dc.creator | Chen, YC;MING-FONG CHEN;Lin, HW;CHUNG-HSI CHOU;Chang, YY;Chiu, CH;Fang, YJ | - |
dc.date.accessioned | 2019-09-26T07:12:40Z | - |
dc.date.available | 2019-09-26T07:12:40Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 0963-9969 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/425332 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-80054716144&doi=10.1016%2fj.foodres.2011.08.004&partnerID=40&md5=1499417a106172ad9ff23afa945d7790 | - |
dc.description.abstract | Chronic alcohol consumption or alcohol abuse is the main cause of alcoholic steatohepatitis or further cirrhosis. This study was to exam if the antioxidant capacity and alcohol metabolism in livers of chronic alcohol-fed rats were improved by supplementing taurine (Tau). Rats were randomly divided into four groups with five times per week of treatment: 1) isocaloric solution; 2) 3. g. alcohol/kg. BW/day; 3) 3. g. alcohol/kg. BW/day. +. 1. g. taurine. (Tau)/kg. BW/day; and 4) 3. g. alcohol/kg. BW/day. +. 2. g Tau/kg. BW/day. A 6-week alcohol consumption resulted in lower (p< 0.05) body weight gain and self-antioxidant capacities, as well as increased (p< 0.05) liver size, serum/hepatic lipids, and AST and ALT values. However, alcohol-fed rats co-treated with Tau have decreased (p< 0.05) liver lipid levels via increasing fecal lipid output and cholesterol metabolism. Besides, co-treatment of Tau also enhanced (p< 0.05) self-antioxidant capacities and alcohol metabolism in livers via enhancing GSH contents, CAT, GSH-Px, ADH, and ALDH activities, but decreasing MDA contents. In a histological examination of rat liver, microvesicular steatosis and necrotic cells were observed in alcohol-fed rats without Tau while largely suppressed microvesicular steatosis and no necrotic cells were observed in alcohol-fed rat supplemented with Tau. Therefore, Tau could be an effective hepatoprotective agent against alcohol-induced damage via enhancing self-antioxidant capacity and alcohol metabolism. © 2011. | en_US |
dc.publisher | ELSEVIER SCIENCE BV | en_US |
dc.relation.ispartof | Food Research International | en_US |
dc.subject | Alcoholic steatohepatitis; Antioxidant capacity; Alcohol metabolism; Liver lipids; Liver damage | en_US |
dc.subject.classification | [SDGs]SDG3 | - |
dc.title | Taurine ameliorates alcoholic steatohepatitis via enhancing self-antioxidant capacity and alcohol metabolism | en_US |
dc.type | journal article | - |
dc.identifier.doi | 10.1016/j.foodres.2011.08.004 | - |
dc.identifier.scopus | 2-s2.0-80054716144 | - |
dc.identifier.isi | WOS:000296798300070 | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/80054716144 | - |
dc.relation.pages | 3105 | en_US |
dc.relation.journalvolume | 44 | en_US |
dc.relation.journalissue | 9 | en_US |
dc.relation.pageend | 3110 | en_US |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Animal Science and Technology | - |
crisitem.author.dept | Veterinary Medicine | - |
crisitem.author.dept | Office of Student Affairs | - |
crisitem.author.dept | Master Program in Global Agriculture Technology and Genomic Science (Global ATGS) | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Animal Science and Technology | - |
crisitem.author.dept | Master Program in Global Agriculture Technology and Genomic Science (Global ATGS) | - |
crisitem.author.orcid | 0000-0002-1209-3852 | - |
crisitem.author.orcid | 0000-0002-4983-2786 | - |
crisitem.author.orcid | 0000-0001-6633-7632 | - |
crisitem.author.orcid | 0000-0002-4616-2115 | - |
crisitem.author.parentorg | College of Bioresources and Agriculture | - |
crisitem.author.parentorg | College of Bioresources and Agriculture | - |
crisitem.author.parentorg | Administrative Unit | - |
crisitem.author.parentorg | International College | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Bioresources and Agriculture | - |
crisitem.author.parentorg | International College | - |
Appears in Collections: | 動物科學技術學系 |
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