|Title:||Nanoemulsified adlay bran oil reduces tyrosinase activity and melanin synthesis in B16F10 cells and zebrafish||Authors:||YU-WEN TING
Chang, Wen Chang
Hu, Jing Yu
Hu, Yin Ting
|Keywords:||adlay bran oil | anti-hyperpigmentation | melanin | nanoemulsion | tyrosinase | zebrafish||Issue Date:||1-Jan-2019||Source:||Food Science and Nutrition||Abstract:||
© 2019 The Authors. Food Science & Nutrition published by Wiley Periodicals, Inc. The efficacy of oily components is often difficult to evaluate due to their incompatibility with most models. Here, we emulsified adlay bran oil (ABO), processed it to a nanoscale, and investigated its anti-hyperpigmentation efficacy, assessed for its inhibitory effects against tyrosinase activity and melanin production, in an in vitro system (mouse melanoma B16F10 cells) and an in vivo system (zebrafish embryos). ABO induced dose-dependent reductions in tyrosinase activity and melanin production in both the melanoma cells and zebrafish, without affecting viability. The efficacy of ABO was strongly influenced by emulsion particle size in the zebrafish but not in the cells. These results indicate that ABO has potential as a tyrosinase inhibitor and anti-hyperpigmentation agent and that the emulsion system is an effective method for delivering the bioactive components of ABO to living systems that could be utilized for other oily components.
|Appears in Collections:||食品科技研究所|
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