https://scholars.lib.ntu.edu.tw/handle/123456789/425870
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ni, Hsing Chang | en_US |
dc.contributor.author | HSIANG-YUAN LIN | en_US |
dc.contributor.author | WEN-YIH TSENG | en_US |
dc.contributor.author | YEN-NAN CHIU | en_US |
dc.contributor.author | Wu, Yu Yu | en_US |
dc.contributor.author | WEN-CHE TSAI | en_US |
dc.contributor.author | SUSAN SHUR-FEN GAU | en_US |
dc.creator | Ni, Hsing Chang;Hsiang-Yuan Lin;Wen-Yih Isaac Tseng;Chiu, Yen Nan;Wu, Yu Yu;Wen-Che Tsai;Susan Shur-Fen Gau | - |
dc.date.accessioned | 2019-10-03T03:16:29Z | - |
dc.date.available | 2019-10-03T03:16:29Z | - |
dc.date.issued | 2018-03-02 | - |
dc.identifier.issn | 02785846 | - |
dc.identifier.uri | https://www2.scopus.com/inward/record.uri?eid=2-s2.0-85034735489&doi=10.1016%2fj.pnpbp.2017.11.008&partnerID=40&md5=4a7f520a3aae3a7b42eea9f42fa86c59 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/425870 | - |
dc.description.abstract | © 2017 The Authors Although recent studies revealed impaired self-regulation (dysregulation) in autism spectrum disorder (ASD), neural correlates of dysregulation and its impacts on autistic neuroanatomy remain unclear. Voxel-based morphometry was applied on structural MRI images in 81 ASD and 61 typically developing (TD) boys aged 7–17 years. Dysregulation was defined by the sum of T-scores of Attention, Aggression, and Anxiety/Depression subscales in the Child Behavior Checklist > 180. There were 53 and 28 boys in the ASD + Dysregulation and ASD-Dysregulation groups, respectively. First, we compared regional gray matter (GM) volume for ASD and TD. Second, we investigated regional GM volumetric differences among the ASD + Dysregulation, ASD-Dysregulation and TD groups. Lastly, shared and distinct neurostructural correlates of dysregulation were investigated in the ASD and TD groups. The ASD-TD difference on neuroanatomy no longer existed after controlling the dysregulation severity. ASD + Dysregulation had larger regional GM volumes in the right fusiform gyrus, and smaller GM volumes in the anterior prefrontal cortex than ASD-Dysregulation and TD, respectively. ASD + Dysregulation had smaller GM volumes in the left lateral occipital/superior parietal cortex than TD boys. No GM difference was identified between ASD-Dysregulation and TD. ASD and TD had a shared association between GM volumes in the orbitofrontal cortex and dysregulation levels. Our findings suggest that atypical neuroanatomy associated with ASD might partially reflect a disproportionate level of impaired self-regulation. Categorical and dimensional considerations of dysregulation should be implemented in future ASD studies. | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Progress in Neuro-Psychopharmacology and Biological Psychiatry | en_US |
dc.subject | Autism spectrum disorder | Child behavior checklist | Dysregulation | Structural MRI | Voxel-based morphometry | en_US |
dc.subject | Autism spectrum disorder; Child behavior checklist; Dysregulation; Structural MRI; Voxel-based morphometry | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | adolescent; aggression; anxiety; Article; attention; autism; autoregulation; brain region; brain size; child; Child Behavior Checklist; clinical feature; controlled study; disease severity; fusiform gyrus; gray matter; human; intelligence quotient; juvenile; major clinical study; male; neuroanatomy; nuclear magnetic resonance imaging; orbital cortex; parietal cortex; prefrontal cortex; scoring system; volumetry; voxel based morphometry; autism; brain; diagnostic imaging; organ size; pathology; psychology; self control; Adolescent; Autism Spectrum Disorder; Brain; Child; Gray Matter; Humans; Magnetic Resonance Imaging; Male; Organ Size; Self-Control | - |
dc.title | Neural correlates of impaired self-regulation in male youths with autism spectrum disorder: A voxel-based morphometry study | en_US |
dc.type | journal article | en |
dc.identifier.doi | https://api.elsevier.com/content/abstract/scopus_id/85034735489 | - |
dc.identifier.doi | 10.1016/j.pnpbp.2017.11.008 | - |
dc.identifier.pmid | 29129723 | - |
dc.identifier.scopus | 2-s2.0-85034735489 | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/85034735489 | - |
dc.relation.journalvolume | 82 | en_US |
dc.relation.pageend | 241 | en_US |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
crisitem.author.dept | Psychiatry | - |
crisitem.author.dept | Psychiatry-NTUH | - |
crisitem.author.dept | Medical Device and Imaging | - |
crisitem.author.dept | Biomedical Engineering | - |
crisitem.author.dept | Brain and Mind Sciences | - |
crisitem.author.dept | Medical Imaging-NTUH | - |
crisitem.author.dept | Psychiatry-NTUH | - |
crisitem.author.dept | Psychiatry | - |
crisitem.author.dept | Psychiatry | - |
crisitem.author.dept | Psychiatry-NTUH | - |
crisitem.author.dept | Psychiatry | - |
crisitem.author.dept | Brain and Mind Sciences | - |
crisitem.author.dept | Psychiatry-NTUH | - |
crisitem.author.orcid | 0000-0001-9519-209X | - |
crisitem.author.orcid | 0000-0002-2314-6868 | - |
crisitem.author.orcid | 0000-0003-1090-396x | - |
crisitem.author.orcid | 0000-0002-9437-5131 | - |
crisitem.author.orcid | 0000-0002-2718-8221 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Engineering | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
Appears in Collections: | 醫療器材與醫學影像研究所 |
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