https://scholars.lib.ntu.edu.tw/handle/123456789/425890
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Lo, Yu Chun | en_US |
dc.contributor.author | YU-JEN CHEN | en_US |
dc.contributor.author | Hsu, Yung Chin | en_US |
dc.contributor.author | WEN-YIH TSENG | en_US |
dc.contributor.author | SUSAN SHUR-FEN GAU | en_US |
dc.creator | SUSAN SHUR-FEN GAU;WEN-YIH ISAAC TSENG;Hsu, Yung Chin;YU-JEN CHEN;Lo, Yu Chun | - |
dc.date.accessioned | 2019-10-03T06:01:35Z | - |
dc.date.available | 2019-10-03T06:01:35Z | - |
dc.date.issued | 2017-05-01 | - |
dc.identifier.issn | 00219630 | - |
dc.identifier.uri | https://www2.scopus.com/inward/record.uri?eid=2-s2.0-84990862331&doi=10.1111%2fjcpp.12641&partnerID=40&md5=55a18892e742d205e2bdbec203596066 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/425890 | - |
dc.description.abstract | © 2016 Association for Child and Adolescent Mental Health. Background: Autism spectrum disorder (ASD) is a neurodevelopmental disorder with social communication deficits as one of the core symptoms. Recently, a five-level model for the social communication has been proposed in which white matter tracts corresponding to each level of the model are identified. Given that the model for social communication subserves social language functions, we hypothesized that the tract integrity of the model for social communication may be reduced in ASD, and the reduction may be related to social communication deficits. Methods: Sixty-two right-handed boys with ASD and 55 typically developing (TD) boys received clinical evaluations, intelligence tests, the Social Communication Questionnaire (SCQ), and MRI scans. Generalized fractional anisotropy (GFA) was measured by diffusion spectrum imaging to indicate the microstructural integrity of the tracts for each level of the social communication model. Group difference in the tract integrity and its relationship with the SCQ subscales of social communication and social interaction were investigated. Results: We found that the GFA values of the superior longitudinal fasciculus III (SLF III, level 1) and the frontal aslant tracts (FAT, level 2) were decreased in ASD compared to TD. Moreover, the GFA values of the SLF III and the FAT were associated with the social interaction subscale in ASD. Conclusions: The tract integrity of the model for social communication is reduced in ASD, and the reduction is associated with impaired social interaction. Our results support that reduced tract integrity of the model for social communication might be a neural substrate of social communication deficits in ASD. | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Journal of Child Psychology and Psychiatry and Allied Disciplines | en_US |
dc.subject | Autism spectrum disorders | brain imaging | communication | en_US |
dc.subject.classification | [SDGs]SDG3 | - |
dc.title | Reduced tract integrity of the model for social communication is a neural substrate of social communication deficits in autism spectrum disorder | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1111/jcpp.12641 | - |
dc.identifier.pmid | 27677901 | - |
dc.identifier.scopus | 2-s2.0-84990862331 | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/84990862331 | - |
dc.relation.pages | 576 | en_US |
dc.relation.journalvolume | 58 | en_US |
dc.relation.journalissue | 5 | en_US |
dc.relation.pageend | 585 | en_US |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
crisitem.author.dept | Medical Device and Imaging | - |
crisitem.author.dept | Biomedical Engineering | - |
crisitem.author.dept | Brain and Mind Sciences | - |
crisitem.author.dept | Medical Imaging-NTUH | - |
crisitem.author.dept | Psychiatry | - |
crisitem.author.dept | Brain and Mind Sciences | - |
crisitem.author.dept | Psychiatry-NTUH | - |
crisitem.author.orcid | 0000-0002-2314-6868 | - |
crisitem.author.orcid | 0000-0002-2718-8221 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Engineering | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 醫療器材與醫學影像研究所 |
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