https://scholars.lib.ntu.edu.tw/handle/123456789/425905
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Ta, A.T. | en_US |
dc.contributor.author | Huang, S.-E. | en_US |
dc.contributor.author | MING-JANG CHIU | en_US |
dc.contributor.author | Hua, M.-S. | en_US |
dc.contributor.author | WEN-YIH TSENG | en_US |
dc.contributor.author | Chen, S.-H.A. | en_US |
dc.contributor.author | Qiu, A. | en_US |
dc.creator | WEN-YIH ISAAC TSENG;Qiu, A.;Chen, S.-H.A.;Hua, M.-S.;MING-JANG CHIU;Huang, S.-E.;Ta, A.T. | - |
dc.date.accessioned | 2019-10-03T08:02:58Z | - |
dc.date.available | 2019-10-03T08:02:58Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 1065-9471 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/425905 | - |
dc.description.abstract | Evidence for an anterior-posterior gradient of age-related volume reduction along the hippocampal longitudinal axis has been reported in normal aging, but functional changes have yet to be systematically investigated. The current study applied an advanced brain mapping technique, large deformation diffeomorphic metric mapping (LDDMM), automatically delineating the hippocampus into the anterior and posterior segments based on anatomical landmarks. We studied this anterior-posterior gradient in terms of structural and functional MRI in 66 participants aged from 19 to 79 years. The results showed age-related structural volume reduction in both anterior and posterior hippocampi, with greater tendency for anterior decrease. FMRI task contrasts that robustly activated the anterior (associative/relational processing) and posterior (novelty) hippocampus independently, showed only significant reduction of activation in the anterior hippocampus as age increased. Our results revealed positive correlation between structural atrophy and functional decrease in the anterior hippocampi, regardless of task performance in normal aging. These findings suggest that anatomy and functions related to the anterior hippocampus may be more vulnerable to aging, than previously thought. © 2011 Wiley Periodicals, Inc. | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Human Brain Mapping | en_US |
dc.subject | Aging | FMRI | Hippocampus | Longitudinal axis | Novelty and relational processing | en_US |
dc.title | Age-related vulnerabilities along the hippocampal longitudinal axis | en_US |
dc.type | journal article | en |
dc.identifier.doi | http://www.scopus.com/inward/record.url?eid=2-s2.0-84866167166&partnerID=MN8TOARS | - |
dc.identifier.doi | 27628106 | - |
dc.identifier.doi | 10.1002/hbm.21364 | - |
dc.identifier.pmid | 21898676 | - |
dc.identifier.scopus | 2-s2.0-84866167166 | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?eid=2-s2.0-84866167166&partnerID=MN8TOARS | - |
dc.relation.pages | 2415 | en_US |
dc.relation.journalvolume | 33 | en_US |
dc.relation.journalissue | 10 | en_US |
dc.identifier.external | 27628106 | - |
dc.relation.pageend | 2427 | en_US |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.languageiso639-1 | en | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Neurology-NTUH | - |
crisitem.author.dept | Neurology | - |
crisitem.author.dept | Biomedical Electronics and Bioinformatics | - |
crisitem.author.dept | Medical Device and Imaging | - |
crisitem.author.dept | Biomedical Engineering | - |
crisitem.author.dept | Brain and Mind Sciences | - |
crisitem.author.dept | Medical Imaging-NTUH | - |
crisitem.author.orcid | 0000-0002-4158-4423 | - |
crisitem.author.orcid | 0000-0002-2314-6868 | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Electrical Engineering and Computer Science | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Engineering | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 醫療器材與醫學影像研究所 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。