|Title:||Shared and distinct alterations of white matter tracts in remitted and nonremitted patients with schizophrenia||Authors:||Huang, Jing Ying
Hsu, Yung Chin
Lin, Yi Tin
Hsieh, Ming Hsien
WEN-YIH ISAAC TSENG
|Keywords:||diffusion MRI | generalized fractional anisotropy | schizophrenia | tract-based analysis | treatment outcome||Issue Date:||1-May-2018||Journal Volume:||39||Journal Issue:||5||Start page/Pages:||2007||Source:||Human Brain Mapping||Abstract:||
© 2018 Wiley Periodicals, Inc. Patients with schizophrenia do not usually achieve remission state even after adequate antipsychotics treatment. Previous studies found significant difference in white matter integrity between patients with good outcomes and those with poor outcomes, but difference is still unclear at individual tract level. This study aimed to use a systematic approach to identify the tracts that were associated with remission state in patients with schizophrenia. We evaluated 91 patients with schizophrenia (remitted, 50; nonremitted, 41) and 50 healthy controls through diffusion spectrum imaging. White matter tract integrity was assessed through an automatic tract-specific analysis method to determine the mean generalized fractional anisotropy (GFA) values of the 76 white matter tract bundles in each participant. Analysis of covariance among the 3 groups revealed 12 tracts that were significantly different in GFA values. Post-hoc analysis showed that compared with the healthy controls, the nonremission group had reduced integrity in all 12 tracts, whereas the remission group had reduced integrity in only 4 tracts. Comparison between the remission and nonremission groups revealed 4 tracts with significant difference (i.e., the right fornix, bilateral uncinate fasciculi, and callosal fibers connecting the temporal poles) even after adjusting age, sex, education year, illness duration, and medication dose. Furthermore, all the 4 tracts were correlated with negative symptoms scores of the positive and negative syndrome scale. In conclusion, our study identified the tracts that were associated with remission state of schizophrenia. These tracts might be a potential prognostic marker for the symptomatic remission in patients with schizophrenia.
|Appears in Collections:||醫療器材與醫學影像研究所|
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