|Title:||Brain connectomics imaging in schizophrenia study||Authors:||WEN-YIH ISAAC TSENG
Hsu, Yung Chin
|Keywords:||Diffusion Spectrum Imaging | Magnetic Resonance Imaging | Schizophrenia | Tract-based automatic analysis | White Matter||Issue Date:||1-Jan-2017||Publisher:||SPIE||Journal Volume:||10251||Source:||Proceedings of SPIE - The International Society for Optical Engineering||Abstract:||
© 2017 SPIE. Schizophrenia is a debilitating mental disorder of which the biological underpinning is still unclear. Increasing evidence in neuroscience has indicated that schizophrenia arises from abnormal connections within or between networks, hence called dysconnectvity syndrome. Recently, we established an automatic method to analyze integrity of the white matter tracts over the whole brain based on diffusion MRI data, named tract-based automatic analysis (TBAA), and used this method to study white matter connection in patients with schizophrenia. We found that alteration of tract integrity is hereditary and inherent; it is found in siblings and in patients in the early phase of disease. Moreover, patients with good treatment outcome and those with poor outcome show distinctly different patterns of alterations, suggesting that these two groups of patients might be distinguishable based on the difference in tract alteration. In summary, the altered tracts revealed by TBAA might become potential biomarkers or trait markers for schizophrenia.
|Appears in Collections:||醫療器材與醫學影像研究所|
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.