https://scholars.lib.ntu.edu.tw/handle/123456789/426393
標題: | Relationship Between Statin Use and Outcomes in Patients Having Cardiac Arrest (from a Nationwide Cohort Study in Taiwan) | 作者: | CHIEN-HUA HUANG Yu, Ping-Hsun MIN-SHAN TSAI HUI-CHUN HUANG TZUNG-DAU WANG WEI-TIEN CHANG Tang, Chao-Hsiun WEN-JONE CHEN CHIEN-HUA HUANG Yu, Ping-Hsun MIN-SHAN TSAI HUI-CHUN HUANG TZUNG-DAU WANG WEI-TIEN CHANG Tang, Chao-Hsiun WEN-JONE CHEN |
公開日期: | 15-五月-2019 | 出版社: | EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC | 卷: | 123 | 期: | 10 | 起(迄)頁: | 1572 | 來源出版物: | The American journal of cardiology | 摘要: | Pretreatment with statins is associated with improved outcomes in severe sepsis, acute coronary syndrome, and stroke. Patients with cardiac arrest experience sepsis-like syndrome and ischemia reperfusion injuries in the heart and brain. The objective of this study was to investigate the effects of statin use before cardiac arrest on outcomes in cardiac arrest patients. Medical records of 142,131 adult patients who experienced nontraumatic cardiac arrest and were resuscitated between 2004 and 2011 were analyzed. Patients were grouped into 2 groups: the "statin group" comprised patients who had received statin treatment for at least 30 days before the cardiac arrest event; the "never statin group" comprised patients who had no statin use within 30 days before the event. Patients with previous statin treatment had better chance of survival to hospital discharge (6.1% vs 4.3%, p <0.0001) and 1-year survival (4.8% vs 3.2%, p <0.0001) after propensity score matching. Previous statin use was an independent predictor for 1-year survival (adjusted odds ratio 1.41, 95% confidence interval 1.16 to 1.71; p = 0.001). A favorable outcome effect of statin on 1-year survival was observed in the presence of diabetes mellitus, chronic kidney disease, and Charlson Comorbidity Index score greater than 5 in the subgroup analysis. In conclusion, statin use before cardiac arrest is associated with 1-year survival in a propensity score-matched nationwide cohort study. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/426393 | ISSN: | 0002-9149 | DOI: | https://api.elsevier.com/content/abstract/scopus_id/85062408751 10.1016/j.amjcard.2019.02.018 |
SDG/關鍵字: | hydroxymethylglutaryl coenzyme A reductase inhibitor; hydroxymethylglutaryl coenzyme A reductase inhibitor; adult; aged; Article; Charlson Comorbidity Index; chronic kidney failure; cohort analysis; controlled study; diabetes mellitus; drug effect; female; heart arrest; hospital discharge; human; independent variable; major clinical study; male; medical record; observational study; predictor variable; priority journal; propensity score; resuscitation; retrospective study; survival rate; Taiwan; treatment duration; treatment outcome; clinical trial; complication; follow up; heart arrest; heart muscle ischemia; incidence; multicenter study; propensity score; register; Aged; Female; Follow-Up Studies; Heart Arrest; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Incidence; Male; Myocardial Ischemia; Propensity Score; Registries; Retrospective Studies; Survival Rate; Taiwan |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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