|Title:||Effectiveness of a reduced dose of efavirenz plus 2 NRTIs as maintenance antiretroviral therapy with the guidance of therapeutic drug monitoring||Authors:||Yang, Shang-Ping
|Issue Date:||2014||Publisher:||JOHN WILEY & SONS LTD||Source:||Journal of the International AIDS Society||Journal Volume:||17||Journal Issue:||4 Suppl 3||Start page/Pages:||24||Abstract:||
Wide inter-patient variation of plasma efavirenz (EFV) concentrations has been observed, and a substantial proportion of HIV-positive patients may have unnecessarily higher plasma EFV concentrations than recommended while receiving EFV-containing combination antiretroviral therapy (cART) at the currently recommended daily dose of 600 mg. A lower daily dose (400 mg) of EFV has recently been demonstrated to be as efficacious as the recommended 600 mg when combined with tenofovir/mtricitabine in a multinational clinical trial, with a lower incidence of adverse effects. We aimed to use a therapeutic drug monitoring (TDM)-guided strategy to optimize the EFV dose in HIV-positive Taiwanese patients.
|Appears in Collections:||臨床藥學研究所|
|論文12_EfavirenzReducedDose_JIAS2014.pdf||75.66 kB||Adobe PDF||View/Open|
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