Repository logo
  • English
  • 中文
Log In
Have you forgotten your password?
  1. Home
  2. College of Medicine / 醫學院
  3. Physical Therapy / 物理治療學系所
  4. Prophylactic NS-21 maintains the skin moisture but does not reduce the severity of radiation dermatitis in patients with head and neck cancer: A randomized control trial
 
  • Details

Prophylactic NS-21 maintains the skin moisture but does not reduce the severity of radiation dermatitis in patients with head and neck cancer: A randomized control trial

Journal
Radiation Oncology
Journal Volume
14
Journal Issue
1
Date Issued
2019-05-30
Author(s)
Chou, Hsiu Ling
Shueng, Pei Wei
Liao, Li Jen
Hsu, Chen Xiong
Kuo, Deng Yu
Lo, Wu Chia
Hou, Pei Yu
LI-YING WANG  
Chou, San Fang
Hsieh, Chen Hsi
DOI
https://api.elsevier.com/content/abstract/scopus_id/85066740091
10.1186/s13014-019-1302-4
URI
https://scholars.lib.ntu.edu.tw/handle/123456789/426605
URL
https://api.elsevier.com/content/abstract/scopus_id/85066740091
Abstract
© 2019 The Author(s). Background: To evaluate the practicality of NS-21 cream with regard to its skin-related toxicity in patients with head and neck cancer (HNC) who are undergoing concurrent chemoradiation therapy (CCRT) or radiotherapy (RT). Methods: Between July 2015 and November 2017, 30 HNC patients who underwent RT or CCRT were randomly allocated to receive either NS-21 or control treatment on their irradiated skin three times per day, starting at the initiation of RT or CCRT and ending 2 weeks after the completion of RT or until the appearance of grade 3 acute radiation dermatitis (ARD). Dermatitis was recorded weekly according to the Common Terminology Criteria for Adverse Events (CTCAE) version 4.0. Skin humidity was monitored by a digital moisture meter. The generalized estimating equation (GEE) and logit link function method were used for statistical analysis. Results: No serious adverse events were observed in either group. Itching dermatitis occurred on the right lower neck in one patient of the NS-21 group during the 3rd week of CCRT, but the severity was mild. The median skin moisture value at the time of the final treatment was significantly different between the study and control groups (30.6 vs. 27.3, p = 0.013). Additionally, there was an inverse relationship between skin moisture and ARD grade (B = -0.04, p = 0.005). The incidence of ARD at the time of the last treatment was not significantly different between the study and control groups (6.7% vs 26.7%, p = 0.165). The risk of grade 3 ARD for skin that had received an irradiation dose of 47-70 Gy was higher than that of skin that had received an irradiation dose ≤46 Gy (OR = 31.06, 95% CI =5.95-162.21, p < 0.001). Nevertheless, the risk of ARD was not significantly different between the groups (OR = 0.38, 95% CI = 0.08-1.74, p = 0.212). Conclusions: NS-21 was well tolerated and effective for the maintenance of skin moisture; however, there was no statistically significant reduction in the risk of ARD in HNC patients undergoing RT or CCRT when compared with HNC patients in the control group. Trial registration: The study was approved by the Institutional Review Board of Far Eastern Memorial Hospital (FEMH-IRB, 104048-F), Registered 1st June 2015,
Subjects
Head and neck cancer | NS-21 | Radiation dermatitis | Skin moisture | Skin toxicity
Head and neck cancer; NS-21; Radiation dermatitis; Skin moisture; Skin toxicity
SDGs

[SDGs]SDG3

Other Subjects
cisplatin; fluorouracil; folinic acid; temiverine; dermatological agent; phenylacetic acid derivative; temiverine; adult; Article; cancer patient; chemoradiotherapy; clinical article; controlled study; dermatitis; disease severity; drug efficacy; drug safety; female; head and neck cancer; human; incidence; male; middle aged; pruritus; radiation dermatitis; radiation dose; randomized controlled trial; risk factor; skin; treatment duration; aged; head and neck tumor; intensity modulated radiation therapy; pathology; radiation dermatitis; radiotherapy dosage; treatment outcome; very elderly; Adult; Aged; Aged, 80 and over; Dermatologic Agents; Female; Head and Neck Neoplasms; Humans; Male; Middle Aged; Phenylacetates; Radiodermatitis; Radiotherapy Dosage; Radiotherapy, Intensity-Modulated; Treatment Outcome
Publisher
BMC
Type
journal article

臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of “NTU Repository” with “Academic Hub” to form NTU Scholars.

總館學科館員 (Main Library)
醫學圖書館學科館員 (Medical Library)
社會科學院辜振甫紀念圖書館學科館員 (Social Sciences Library)

開放取用是從使用者角度提升資訊取用性的社會運動,應用在學術研究上是透過將研究著作公開供使用者自由取閱,以促進學術傳播及因應期刊訂購費用逐年攀升。同時可加速研究發展、提升研究影響力,NTU Scholars即為本校的開放取用典藏(OA Archive)平台。(點選深入了解OA)

  • 請確認所上傳的全文是原創的內容,若該文件包含部分內容的版權非匯入者所有,或由第三方贊助與合作完成,請確認該版權所有者及第三方同意提供此授權。
    Please represent that the submission is your original work, and that you have the right to grant the rights to upload.
  • 若欲上傳已出版的全文電子檔,可使用Open policy finder網站查詢,以確認出版單位之版權政策。
    Please use Open policy finder to find a summary of permissions that are normally given as part of each publisher's copyright transfer agreement.
  • 網站簡介 (Quickstart Guide)
  • 使用手冊 (Instruction Manual)
  • 線上預約服務 (Booking Service)
  • 方案一:臺灣大學計算機中心帳號登入
    (With C&INC Email Account)
  • 方案二:ORCID帳號登入 (With ORCID)
  • 方案一:定期更新ORCID者,以ID匯入 (Search for identifier (ORCID))
  • 方案二:自行建檔 (Default mode Submission)
  • 方案三:學科館員協助匯入 (Email worklist to subject librarians)

Built with DSpace-CRIS software - Extension maintained and optimized by 4Science